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	Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese
	Lan, Jie1; Song, Manshu2; Pan, Chunhui1; Zhuang, Guoqing1; Wang, Youxin2; Ma, Wenzhan1; Chu, Qiaoyun1; Lai, Qingxuan1; Xu, Feng1; Li, Yanli1
刊名	Journal of human genetics
	2009-08-01
卷号	54期号:8页码:457-460
关键词	Case-control study Dopamine d2 receptor Dopamine transporter Disorder of fluent speech Han chinese Snps
ISSN号	1434-5161
DOI	10.1038/jhg.2009.60
通讯作者	Wang, wei(wei6014@yahoo.com)
英文摘要	Normal function of the dopaminergic system is necessary for speech fluency. there was evidence that the activities of dopamine transporter (dat) and dopamine d2 receptor (drd2) could be altered in people with speech disfluency. this study aims to ascertain the possible correlation between two dopaminergic genes (slc6a3 and drd2) and disorder of speech fluency, and to determine the allelic frequencies of the five single-nucleotide polymorphisms (snps) (rs2617604, rs28364997, rs28364998 in slc6a3 and rs6275, rs6277 in drd2) among han chinese patients with this disorder. a sample of 112 patients with speech disfluency and 112 gender-matched controls were included in this case-control study. the results show that the presence of c allele at rs6277 in drd2 gene is associated with increased susceptibility to the disorder, whereas t allele is protective. haplotype 939t/957t is also a protective factor. journal of human genetics (2009) 54, 457-460; doi: 10.1038/jhg.2009.60; published online 10 july 2009
WOS关键词	ATTENTION-DEFICIT HYPERACTIVITY ; C957T POLYMORPHISM ; RISPERIDONE ; DISORDER ; FLUENCY ; SPEECH
WOS研究方向	Genetics & Heredity
WOS类目	Genetics & Heredity
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000269939000004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2394336
专题	中国科学院大学
通讯作者	Wang, Wei
作者单位	1.Chinese Acad Sci, Dept Genet, Coll Life Sci, Grad Univ, Beijing 100049, Peoples R China 2.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing, Peoples R China 3.Curtin Univ Technol, Sch Publ Hlth, Perth, WA, Australia
推荐引用方式 GB/T 7714	Lan, Jie,Song, Manshu,Pan, Chunhui,et al. Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese[J]. Journal of human genetics,2009,54(8):457-460.
APA	Lan, Jie.,Song, Manshu.,Pan, Chunhui.,Zhuang, Guoqing.,Wang, Youxin.,...&Wang, Wei.(2009).Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese.Journal of human genetics,54(8),457-460.
MLA	Lan, Jie,et al."Association between dopaminergic genes (slc6a3 and drd2) and stuttering among han chinese".Journal of human genetics 54.8(2009):457-460.

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