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	Transgenic analyses of tgif family proteins in drosophila imply their role in cell growth
	Wang, Yonghua1,2; Wang, Lixia1; Wang, Zhaohui1
刊名	Journal of genetics and genomics
	2008-08-01
卷号	35期号:8页码:457-465
关键词	Tgif Cell size Cell proliferation Transgenic Drosophila melanogaster
ISSN号	1673-8527
通讯作者	Wang, zhaohui(zhwang@genetics.ac.cn)
英文摘要	Tg-interacting factors (tgifs) belong to a family of tale-homeodomain proteins including tgif, tgif2, and tgif2lx/y (tgif2 like on x or y chromosome) in human. they potentially play important functions in various tissues during development. mutations in tgif are frequently associated with malformation of forebrain and facial structures; tgif2 proteins are over-expressed in many ovarian cancer cell lines; and tgif2lx/y are specifically expressed in adult testis. the molecular functions of these proteins have been investigated mostly in cultured cells. tgif and tgif2 have been found as transcriptional repressors that modulate tgf-beta signaling. however, these findings are far from sufficient to explain their mutant phenotypes or expression patterns, and the functions of tgif2lx/y have never been reported. here we use drosophila as a model system to explore the functions of tgif family proteins in vivo. we observed in fly tissues such as fat body, epithelia, and neuronal cells, that expressing human tgif2 or human tgif2lx generally inhibited cell growth in size and number. co-expressing drosophila myc, cyclin e, or human c-mycs partially rescued the growth inhibition induced by human tgifs, whereas activated insulin pathway signaling did not. taken together, we provide in in vivo evidence for the potential functions of human tgif2 and tgif2lx in growth control. additionally, we confirmed that drosophila tglfs are transcriptional activators by assaying their activities in spermatogenesis.
WOS关键词	TRANSCRIPTIONAL COREPRESSOR TGIF ; FUNCTIONAL-ANALYSIS ; SIGNALING PATHWAY ; GENE ; SPERMATOGENESIS ; PROLIFERATION ; MELANOGASTER ; METABOLISM ; MUTATIONS ; DIVISION
WOS研究方向	Biochemistry & Molecular Biology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Genetics & Heredity
语种	英语
出版者	SCIENCE PRESS
WOS记录号	WOS:000259761200002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2384682
专题	中国科学院大学
通讯作者	Wang, Zhaohui
作者单位	1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yonghua,Wang, Lixia,Wang, Zhaohui. Transgenic analyses of tgif family proteins in drosophila imply their role in cell growth[J]. Journal of genetics and genomics,2008,35(8):457-465.
APA	Wang, Yonghua,Wang, Lixia,&Wang, Zhaohui.(2008).Transgenic analyses of tgif family proteins in drosophila imply their role in cell growth.Journal of genetics and genomics,35(8),457-465.
MLA	Wang, Yonghua,et al."Transgenic analyses of tgif family proteins in drosophila imply their role in cell growth".Journal of genetics and genomics 35.8(2008):457-465.

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