| Studies on the biotransformation of 16-o-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria | |
| Zhao Yu-Feng1,2; Song Feng-Rui1; Yue Hao1; Guo Xin-Hua1; Li Hui-Lin1; Liu Zhi-Qiang1; Liu Su-Ying1 | |
| 刊名 | Chinese journal of analytical chemistry
 |
| 2007-12-01 | |
| 卷号 | 35期号:12页码:1711-1715 |
| 关键词 | 16-o-demethyldeoxyaconitine Human intestinal bacteria Biotransformation Electrospray ionization mass spectrometry |
| ISSN号 | 0253-3820 |
| 通讯作者 | Liu su-ying(syliu19@yahoo.com.cn) |
| 英文摘要 | To study the biotransformation of 16-o-demethyldeoxyaconitine in human intestine, aconitine was incubated with human intestinal bacteria in vitro. the metabolites of 16-o-demethyldeoxyaconitine were directly investigated using electrospray ionization tandem mass spectrometry (esi-ms"). aconitum alkaloids formed protonated molecule [m + h](+) in the positive ion mode. 16-o-demethyldeoxyaconitine can be transformed by human intestinal bacteria. it was converted into more than 10 kinds of new metabolites such as mono-ester alkaloids, diester alkaloids and lipo-alkaloids by deacetylation, debenzoyltion, dehydroxylation, demethylation and esterification. diester alkaloids are very toxical. however, the toxicity of mono-ester alkaloids and lipo-alkaloids are less than that of diester alkaloids. when 16-o-demethyldeoxyaconitine was transfor med into mono-ester alkaloids and lipo-alkaloids by human intestinal bacteria, the toxicity degraded. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; CARMIECHAELI |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| 出版者 | SCIENCE CHINA PRESS |
| WOS记录号 | WOS:000253934500005 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2380110 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu Su-Ying |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Yu-Feng,Song Feng-Rui,Yue Hao,et al. Studies on the biotransformation of 16-o-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria[J]. Chinese journal of analytical chemistry,2007,35(12):1711-1715. |
| APA | Zhao Yu-Feng.,Song Feng-Rui.,Yue Hao.,Guo Xin-Hua.,Li Hui-Lin.,...&Liu Su-Ying.(2007).Studies on the biotransformation of 16-o-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria.Chinese journal of analytical chemistry,35(12),1711-1715. |
| MLA | Zhao Yu-Feng,et al."Studies on the biotransformation of 16-o-demethyldeoxyaconitine of the metabolite of aconitine in human intestinal bacteria".Chinese journal of analytical chemistry 35.12(2007):1711-1715. |
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