| The immunopharmacological properties of transforming growth factor beta | |
| Le, YY; Yu, XJ; Ruan, LF; Wang, OM; Qi, DF; Zhu, JJ; Lu, XF; Kong, Y; Cai, K; Pang, SS | |
| 刊名 | International immunopharmacology
 |
| 2005-12-01 | |
| 卷号 | 5期号:13-14页码:1771-1782 |
| 关键词 | Transforming growth factor beta Inflammation Alzheimer's disease |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2005.07.006 |
| 通讯作者 | Le, yy(yyle@sibs.ac.cn) |
| 英文摘要 | Transforming growth factor-beta (tgf-beta) family members are multifunctional molecules, which play pivotal roles in regulating cell proliferation, differentiation, migration, development, tissue remodeling and repair. these events are closely associated with host immune responses and inflammation. despite some controversies on their function in controlling dendritic and t regulatory cell development and activity, the importance of tgf-beta s in the progress of autoimmunity and inflammatory diseases has been well appreciated and new aspects of their contribution continue to be recognized. since one of the major biological properties of tgf-beta s is its capacity to potently suppress immune responses, they are considered as candidates for the development of therapeutic agents to fend off undesirable damage associated with immune and inflammatory conditions. (c) 2005 elsevier b.v. all rights reserved. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; REGULATORY T-CELLS ; RECEPTOR-TYPE-II ; MURINE MICROGLIAL CELLS ; TGF-BETA ; ALZHEIMERS-DISEASE ; TRANSGENIC MICE ; TARGETED DISRUPTION ; IN-VIVO ; SYNOVIAL FIBROBLASTS |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| WOS类目 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000233686600002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2377557 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Le, YY |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Lab Immunol & Inflammatory Dis, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China 3.NCI, Mol Immunoregulat Lab, Canc Res Ctr, Frederick, MD 21702 USA |
| 推荐引用方式 GB/T 7714 | Le, YY,Yu, XJ,Ruan, LF,et al. The immunopharmacological properties of transforming growth factor beta[J]. International immunopharmacology,2005,5(13-14):1771-1782. |
| APA | Le, YY.,Yu, XJ.,Ruan, LF.,Wang, OM.,Qi, DF.,...&Wang, JM.(2005).The immunopharmacological properties of transforming growth factor beta.International immunopharmacology,5(13-14),1771-1782. |
| MLA | Le, YY,et al."The immunopharmacological properties of transforming growth factor beta".International immunopharmacology 5.13-14(2005):1771-1782. |
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