| Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the chinese han population | |
| Wan, CL; Yang, YF; Feng, GY; Gu, NF; Liu, HJ; Zhu, SM; He, L; Wang, L | |
| 刊名 | Neuroscience letters
 |
| 2005-11-18 | |
| 卷号 | 388期号:3页码:126-131 |
| 关键词 | Schizophrenia Myelin-associated glycoprotein Polymorphisms Association study |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2005.06.051 |
| 通讯作者 | Wang, l() |
| 英文摘要 | Results of gene expression microarray and quantitative pcr studies have suggested abnormalities in the expression of myelin-related genes including myelin-associated glycoprotein (mag) in schizophrenic patients. research provides strong evidence for oligodendrocyte dysfunction in schizophrenics. in order to further assess the role of mag in schizophrenia, we examined four single nucleotide polymorphisms (snps), namely rs2301600, rs3746248, rs720309 and rs720308, of this gene in chinese schizophrenic patients (n = 470) and healthy controls (n = 470). the distribution of rs720309 t/a genotypes showed a strong association with schizophrenia (chi(2) = 14.58, d.f. = 2, p = 0.0008). a haplotype constructed of rs720309-rs720308 also revealed a significant association with schizophrenia (chi(2) = 11.914, d.f. = 3, p = 0.0084). our findings of a significant associations between schizophrenia and the mag gene suggest that this gene may be involved in susceptibility to schizophrenia in the chinese han population. (c) 2005 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | FAMILY-BASED ASSOCIATION ; ALLELE-FREQUENCY ; BIPOLAR DISORDER ; ABNORMALITIES ; DISEASE ; LOCUS ; DISEQUILIBRIUM ; IDENTIFICATION ; REGENERATION ; INHIBITOR |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| 出版者 | ELSEVIER IRELAND LTD |
| WOS记录号 | WOS:000231943900002 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2377425 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, L |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China 2.Chinese Acad Sci, Ctr Human & Anim Genet, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 5.Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China 6.Jilin Inst Mental Hlth, Jilin 136000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, CL,Yang, YF,Feng, GY,et al. Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the chinese han population[J]. Neuroscience letters,2005,388(3):126-131. |
| APA | Wan, CL.,Yang, YF.,Feng, GY.,Gu, NF.,Liu, HJ.,...&Wang, L.(2005).Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the chinese han population.Neuroscience letters,388(3),126-131. |
| MLA | Wan, CL,et al."Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the chinese han population".Neuroscience letters 388.3(2005):126-131. |
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