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	Classification of hiv-1-mediated neuronal dendritic and synaptic damage using multiple criteria linear programming
	Zheng, JL; Zhuang, W; Yan, N; Kou, G; Peng, H; McNally, C; Erichsen, D; Cheloha, A; Herek, S; Shi, C
刊名	Neuroinformatics
	2004-09-01
卷号	2期号:3页码:303-326
关键词	Neuronal damage Hiv-1-associated dementia Data mining Classification Multi-criteria linear programming Dendritic morphology
ISSN号	1539-2791
通讯作者	Shi, y()
英文摘要	The ability to identify neuronal damage in the dendritic arbor during hiv-1-associated dementia (had) is crucial for designing specific therapies for the treatment of had. to study this process, we utilized a computer-based image analysis method to quantitatively assess hiv-1 viral protein gp120 and glutamate-mediated individual neuronal damage in cultured cortical neurons. changes in the number of neurites, arbors, branch nodes, cell body area, and average arbor lengths were determined and a database was formed (http://dm.st.unomaha. edu/database.htm). we further proposed a two-class model of multiple criteria linear programming (mclp) to classify such hiv-1-mediated neuronal dendritic and synaptic damages. given certain classes, including treatments with brain-derived neurotrophic factor (bdnf), glutamate, gp120 or non-treatment controls from our in vitro experimental systems, we used the two-class mclp model to determine the data patterns between classes in order to gain insight about neuronal dendritic damages. this knowledge can be applied in principle to the design and study of specific therapies for the prevention or reversal of neuronal damage associated with had. finally, the mclp method was compared with a well-known artificial neural network algorithm to test for the relative potential of different data mining applications in had research.
WOS关键词	HUMAN-IMMUNODEFICIENCY-VIRUS ; HIV-ASSOCIATED DEMENTIA ; NECROSIS-FACTOR-ALPHA ; NERVE GROWTH-FACTOR ; AIDS DEMENTIA ; HIV-1-INFECTED MACROPHAGES ; HIV-1-ASSOCIATED DEMENTIA ; DISCRIMINANT-ANALYSIS ; HUMAN BRAIN ; APOPTOSIS
WOS研究方向	Computer Science ; Neurosciences & Neurology
WOS类目	Computer Science, Interdisciplinary Applications ; Neurosciences
语种	英语
出版者	HUMANA PRESS INC
WOS记录号	WOS:000224332800004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376871
专题	中国科学院大学
通讯作者	Shi, Y
作者单位	1.Univ Nebraska, Coll Informat Sci & Technol, Omaha, NE 68182 USA 2.Univ Nebraska, Med Ctr, Lab Neurotoxicol, Ctr Neurovirol & Neurodegenerat Disorders,Dept Pa, Omaha, NE 68198 USA 3.Univ Nebraska, Med Ctr, Dept Microbiol, Omaha, NE 68198 USA 4.Univ Nebraska, Med Ctr, Dept Pharmacol, Omaha, NE 68198 USA 5.Univ Minnesota, Coll Biol Sci, St Paul, MN 55108 USA 6.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zheng, JL,Zhuang, W,Yan, N,et al. Classification of hiv-1-mediated neuronal dendritic and synaptic damage using multiple criteria linear programming[J]. Neuroinformatics,2004,2(3):303-326.
APA	Zheng, JL.,Zhuang, W.,Yan, N.,Kou, G.,Peng, H.,...&Shi, Y.(2004).Classification of hiv-1-mediated neuronal dendritic and synaptic damage using multiple criteria linear programming.Neuroinformatics,2(3),303-326.
MLA	Zheng, JL,et al."Classification of hiv-1-mediated neuronal dendritic and synaptic damage using multiple criteria linear programming".Neuroinformatics 2.3(2004):303-326.

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