| Braf gene: from human cancers to developmental syndromes | |
| Hussain, Muhammad Ramzan Manwar1,6; Baig, Mukhtiar2; Mohamoud, Hussein Sheik Ali3; Ulhaq, Zaheer4; Hoessli, Daniel C.4; Khogeer, Ghaidaa Siraj5; Al-Sayed, Ranem Radwan5; Al-Aama, Jumana Yousuf1 | |
| 刊名 | Saudi journal of biological sciences
 |
| 2015-07-01 | |
| 卷号 | 22期号:4页码:359-373 |
| 关键词 | Braf gene Ras-raf overactivation Cancers Developmental syndromes |
| ISSN号 | 1319-562X |
| DOI | 10.1016/j.sjbs.2014.10.002 |
| 通讯作者 | Hussain, muhammad ramzan manwar(geniouschemist26@gmail.com) |
| 英文摘要 | The braf gene encodes for a serine/threonine protein kinase that participates in the mapk/erk signalling pathway and plays a vital role in cancers and developmental syndromes (rasopathies). the current review discusses the clinical significance of the braf gene and other members of ras/raf cascade in human cancers and ras/mapk syndromes, and focuses the molecular basis and clinical genetics of braf to better understand its parallel involvement in both tumourigenesis and ras/mapk syndromes--noonan syndrome, cardio-facio-cutaneous syndrome and leopard syndrome. (c) 2014 production and hosting by elsevier b.v. on behalf of king saud university. |
| WOS关键词 | PAPILLARY THYROID-CANCER ; FACIO-CUTANEOUS SYNDROME ; HAIRY-CELL LEUKEMIA ; NONPOLYPOSIS COLORECTAL-CANCER ; NOONAN-SYNDROME PHENOTYPE ; MUTATIONS CAUSE NOONAN ; V600E MUTATION ; MICROSATELLITE INSTABILITY ; PROSTATE-CANCER ; KRAS MUTATIONS |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000355922900001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2376756 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hussain, Muhammad Ramzan Manwar |
| 作者单位 | 1.King Abdulaziz Univ, Fac Genet Med, Jeddah 21413, Saudi Arabia 2.King Abdulaziz Univ, Fac Med, Rabigh Branch, Jeddah 21413, Saudi Arabia 3.St Georges Univ London, Human Genet Res Ctr, Div Biomed Sci BMS, London, England 4.Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi 75270, Pakistan 5.King Abdulaziz Univ, Dept Biol, Genom & Biotechnol Sect, Jeddah 21413, Saudi Arabia 6.Univ Chinese Acad Sci, CAS Inst Microbiol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hussain, Muhammad Ramzan Manwar,Baig, Mukhtiar,Mohamoud, Hussein Sheik Ali,et al. Braf gene: from human cancers to developmental syndromes[J]. Saudi journal of biological sciences,2015,22(4):359-373. |
| APA | Hussain, Muhammad Ramzan Manwar.,Baig, Mukhtiar.,Mohamoud, Hussein Sheik Ali.,Ulhaq, Zaheer.,Hoessli, Daniel C..,...&Al-Aama, Jumana Yousuf.(2015).Braf gene: from human cancers to developmental syndromes.Saudi journal of biological sciences,22(4),359-373. |
| MLA | Hussain, Muhammad Ramzan Manwar,et al."Braf gene: from human cancers to developmental syndromes".Saudi journal of biological sciences 22.4(2015):359-373. |
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