| Computational analysis of anmk-like kinase: new insights into the cell wall metabolism of fungi | |
| Dai, Jianghong1,2; Qu, Hong3; Yu, Zhisheng2; Yang, Jiangke1; Zhang, Hongxun2 | |
| 刊名 | Journal of theoretical biology
 |
| 2015-08-21 | |
| 卷号 | 379页码:59-65 |
| 关键词 | Homology modeling Molecular docking Peptidoglycan Chitin Cell wall |
| ISSN号 | 0022-5193 |
| DOI | 10.1016/j.jtbi.2015.05.004 |
| 通讯作者 | Dai, jianghong(daijh333@aliyun.com) |
| 英文摘要 | 1,6-anhydro-n-acetylmuramic acid kinase (anmk) is the unique enzyme that marks the recycling of the cell wall of escherichia colt. here, 81 fungal anmk-like kinase sequences from 57 fungal species were searched in the ncbi database and a phylogenetic tree was constructed. the three-dimensional structure of an anmk-like kinase, levoglucosan kinase (lgk) of the yeast lipomyces starkeyi, was modeled; molecular docking revealed that anmk and lgk are conserved proteins, and 187asp, 212asp are enzymatic residues, respectively. analysis suggests that 1,6-anhydro-n-acetylglucosamine (anhglcnac) and/or 1,6-anhydro-beta-d-glucosamine (anhglcn) would be the appropriate substrates of anmk-like kinases. also, the counterparts of other characteristic enzymes of cell wall recycling of bacteria were found in fungi. taken together, it is proposed that a putative recycling of anhglcnac/anhglcn, which is associated with the hydrolysis of cell walls, exists in fungi. this computational analysis will provide new insights into the metabolism of fungal cell walls. (c) 2015 elsevier ltd. all rights reserved. |
| WOS关键词 | N-ACETYLGLUCOSAMINE-PHOSPHATE ; ESCHERICHIA-COLI ; LEVOGLUCOSAN 1,6-ANHYDRO-BETA-D-GLUCOPYRANOSE ; HYPHAL GROWTH ; CHITINASES ; PURIFICATION ; MUREIN ; MICROORGANISMS ; IDENTIFICATION ; PEPTIDOGLYCAN |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
| WOS类目 | Biology ; Mathematical & Computational Biology |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000356839700007 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2376423 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianghong |
| 作者单位 | 1.Wuhan Polytech Univ, Sch Biol & Pharmaceut Engn, Wuhan 430023, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Peking Univ, Coll Life Sci, State Key Lab Prot & Plant Gene Res, Ctr Bioinformat, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Jianghong,Qu, Hong,Yu, Zhisheng,et al. Computational analysis of anmk-like kinase: new insights into the cell wall metabolism of fungi[J]. Journal of theoretical biology,2015,379:59-65. |
| APA | Dai, Jianghong,Qu, Hong,Yu, Zhisheng,Yang, Jiangke,&Zhang, Hongxun.(2015).Computational analysis of anmk-like kinase: new insights into the cell wall metabolism of fungi.Journal of theoretical biology,379,59-65. |
| MLA | Dai, Jianghong,et al."Computational analysis of anmk-like kinase: new insights into the cell wall metabolism of fungi".Journal of theoretical biology 379(2015):59-65. |
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