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	Increased levels of antibiotic resistance in urban stream of jiulongjiang river, china
	Ouyang, Wei-Ying1,2; Huang, Fu-Yi1; Zhao, Yi1; Li, Hu1,2; Su, Jian-Qiang1
刊名	Applied microbiology and biotechnology
	2015-07-01
卷号	99期号:13页码:5697-5707
关键词	Antibiotic resistance Urbanization Urban stream High-throughput qpcr Multi-resistant bacteria
ISSN号	0175-7598
DOI	10.1007/s00253-015-6416-5
通讯作者	Su, jian-qiang(jqsu@iue.ac.cn)
英文摘要	The rapid global urbanization and other extensive anthropogenic activities exacerbated the worldwide human health risks induced by antibiotic resistance genes (args). knowledge of the origins and dissemination of args is essential for understanding modern resistome, while little information is known regarding the overall resistance levels in urban river. in this study, the abundance of multi-resistant bacteria (mrb) and args was investigated using culture-based method and high-throughput qpcr in water samples collected from urban stream and source of jiulongjiang river, china, respectively. the abundance of mrb (conferring resistance to three combinations of antibiotics and vancomycin) was significantly higher in urban samples. a total of 212 args were detected among all the water samples, which encoded resistance to almost all major classes of antibiotics and encompassed major resistant mechanisms. the total abundance of args in urban samples (ranging from 9.72x10(10) to 1.03x10(11) copies l-1) was over two orders of magnitude higher than that in pristine samples (7.18x10(8) copies l-1), accompanied with distinct args structures, significantly higher diversity, and enrichment of args. significant correlations between the abundance of args and mobile genetic elements (mges) were observed, implicating the potential of horizontal transfer of args. high abundance and enrichment of diverse args and mges detected in urban river provide evidence that anthropogenic activities are responsible for the emergence and dissemination of args to the urban river and management options should be taken into account for minimizing the spread of args.
WOS关键词	WATER TREATMENT PLANTS ; CLASS 1 INTEGRONS ; WASTE-WATER ; ESCHERICHIA-COLI ; MOLECULAR SIGNATURES ; METAGENOMIC ANALYSIS ; HOSPITAL EFFLUENT ; CLASS-1 INTEGRONS ; MANURE WASTE ; GENES
WOS研究方向	Biotechnology & Applied Microbiology
WOS类目	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000356805600030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376376
专题	中国科学院大学
通讯作者	Su, Jian-Qiang
作者单位	1.Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ouyang, Wei-Ying,Huang, Fu-Yi,Zhao, Yi,et al. Increased levels of antibiotic resistance in urban stream of jiulongjiang river, china[J]. Applied microbiology and biotechnology,2015,99(13):5697-5707.
APA	Ouyang, Wei-Ying,Huang, Fu-Yi,Zhao, Yi,Li, Hu,&Su, Jian-Qiang.(2015).Increased levels of antibiotic resistance in urban stream of jiulongjiang river, china.Applied microbiology and biotechnology,99(13),5697-5707.
MLA	Ouyang, Wei-Ying,et al."Increased levels of antibiotic resistance in urban stream of jiulongjiang river, china".Applied microbiology and biotechnology 99.13(2015):5697-5707.

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