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	Diverse alternative back-splicing and alternative splicing landscape of circular rnas
	Zhang, Xiao-Ou1,2; Dong, Rui1,2; Zhang, Yang2,3; Zhang, Jia-Lin1,2,3; Luo, Zheng1,2; Zhang, Jun3; Chen, Ling-Ling2,3,4; Yang, Li1,2,4
刊名	Genome research
	2016-09-01
卷号	26期号:9页码:1277-1287
ISSN号	1088-9051
DOI	10.1101/gr.202895.115
通讯作者	Chen, ling-ling(linglingchen@sibcb.ac.cn) ; Yang, li(liyang@picb.ac.cn)
英文摘要	Circular rnas (circrnas) derived from back-spliced exons have been widely identified as being co-expressed with their linear counterparts. a single gene locus can produce multiple circrnas through alternative back-splice site selection and/or alternative splice site selection; however, a detailed map of alternative back-splicing/splicing in circrnas is lacking. here, with the upgraded circexplorer2 pipeline, we systematically annotated different types of alternative back-splicing and alternative splicing events in circrnas from various cell lines. compared with their linear cognate rnas, circrnas exhibited distinct patterns of alternative back-splicing and alternative splicing. alternative back-splice site selection was correlated with the competition of putative rna pairs across introns that bracket alternative back-splice sites. in addition, all four basic types of alternative splicing that have been identified in the (linear) mrna process were found within circrnas, and many exons were predominantly spliced in circrnas. unexpectedly, thousands of previously unannotated exons were detected in circrnas from the examined cell lines. although these novel exons had similar splice site strength, they were much less conserved than known exons in sequences. finally, both alternative back-splicing and circrna-predominant alternative splicing were highly diverse among the examined cell lines. all of the identified alternative back-splicing and alternative splicing in circrnas are available in the circpedia database (http://www.picb.ac.cn/rnomics/circpedia). collectively, the annotation of alternative back -splicing and alternative splicing in circrnas provides a valuable resource for depicting the complexity of circrna biogenesis and for studying the potential functions of circrnas in different cells.
WOS关键词	EXON CIRCULARIZATION ; CIRCRNA BIOGENESIS ; TRANSCRIPTION ; REVEALS ; REPEATS ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
WOS类目	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity
语种	英语
出版者	COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
WOS记录号	WOS:000382421000013
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376340
专题	中国科学院大学
通讯作者	Chen, Ling-Ling; Yang, Li
作者单位	1.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, CAS MPG Partner Inst Computat Biol,Key Lab Comput, Shanghai 200031, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Mol, Shanghai 200031, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci, Shanghai 20003, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Xiao-Ou,Dong, Rui,Zhang, Yang,et al. Diverse alternative back-splicing and alternative splicing landscape of circular rnas[J]. Genome research,2016,26(9):1277-1287.
APA	Zhang, Xiao-Ou.,Dong, Rui.,Zhang, Yang.,Zhang, Jia-Lin.,Luo, Zheng.,...&Yang, Li.(2016).Diverse alternative back-splicing and alternative splicing landscape of circular rnas.Genome research,26(9),1277-1287.
MLA	Zhang, Xiao-Ou,et al."Diverse alternative back-splicing and alternative splicing landscape of circular rnas".Genome research 26.9(2016):1277-1287.

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