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	Activation and identification of nc-1: a cryptic cyclodepsipeptide from red soil-derived streptomyces sp fxj1.172
	Liu, Minghao1,2; Liu, Ning1; Shang, Fei3; Huang, Ying1
刊名	European journal of organic chemistry
	2016-08-01
期号	23页码:3943-3948
关键词	Natural products Structure elucidation Configuration determination Depsipeptides Genome mining
ISSN号	1434-193X
DOI	10.1002/ejoc.201600297
通讯作者	Huang, ying(huangy@im.ac.cn)
英文摘要	Genome sequence analysis of a lasalocid-producing strain, streptomyces sp. fxj1.172, which was isolated from red soil, indicated its great untapped biosynthetic potential for novel secondary metabolites. a lasalocid-null mutant streptomyces sp. fxj1.172lods, was then constructed to make way for the cryptic biosynthetic pathways. consequently, a novel cyclodepsipeptide, named nc-1, was activated and isolated from the lasalocid abolished mutant strain cultivated in glucose-yeast extract-malt extract (gym) medium supplemented with ferric ion. the planar- and stereo-structures of nc-1 were elucidated based on detailed analyses of ms, nmr, and single-crystal x-ray diffraction data, revealing it as the first reported cyclodepsipeptide that is epoxidized at adjacent carbon atoms of the cinnamoyl fatty acid side chain. in assays of antimicrobial activity, nc-1 exhibited moderate inhibition effects against mycobacterium bovis bacille calmette-guerin (bcg).
WOS关键词	NONRIBOSOMAL PEPTIDE SYNTHETASE ; ANTIBIOTIC PRODUCTION ; DISCOVERY ; BIOSYNTHESIS ; INHIBITORS ; PRODUCTS ; WS9326A ; DNA
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000382962700005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376244
专题	中国科学院大学
通讯作者	Huang, Ying
作者单位	1.Chinese Acad Sci, State Key Lab Microbial Resources, Inst Microbiol, 1 Beichen West Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Beijing Univ Chem Technol, Analyt & Testing Ctr, Beijing 100029, Peoples R China
推荐引用方式 GB/T 7714	Liu, Minghao,Liu, Ning,Shang, Fei,et al. Activation and identification of nc-1: a cryptic cyclodepsipeptide from red soil-derived streptomyces sp fxj1.172[J]. European journal of organic chemistry,2016(23):3943-3948.
APA	Liu, Minghao,Liu, Ning,Shang, Fei,&Huang, Ying.(2016).Activation and identification of nc-1: a cryptic cyclodepsipeptide from red soil-derived streptomyces sp fxj1.172.European journal of organic chemistry(23),3943-3948.
MLA	Liu, Minghao,et al."Activation and identification of nc-1: a cryptic cyclodepsipeptide from red soil-derived streptomyces sp fxj1.172".European journal of organic chemistry .23(2016):3943-3948.

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