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	Immunomodulating components from chinese medicines
	Li, XY
刊名	Pharmaceutical biology
	2000
卷号	38页码:33-40
关键词	Acanthopanax senticosus Achyranthes bidentata Astragalus mongholicus Chinese medicine Coriolus versicolor Immunomodulator Ginkgo biloba Polysaccharide Terpene Tripterygium wilfordii
ISSN号	1388-0209
通讯作者	Li, xy(xyli@mail.shcnc.ac.cn)
英文摘要	Modern scientific studies have shown that several components from chinese herbal medicines are immunologically active. astragalus mongholicus polysaccharide aps, a polymer of glucose and arabinose, increases specific antibody formation as well as synthesis of rna, dna and protein in mouse spleen. the polysaccharide pes isolated from acanthopanax senticosus used as a tonic and sedative agent also induces interferon production. an oligosaccharide abps isolated from achyranthes bidentala with a mw of only 1360 da significantly enhances the humoral immune response and antagonizes the immunosuppressive effects of cyclosporin a. abps increases the production of tnf and the activity of nk cells. in tumor patients treated by chemotherapy or radiotherapy, abps maintained their peripheral white blood cell count and improved the quality of life. psp, the protein bound polysaccharide extracted from coriolus versicolor, has been developed as an anticancer drug in china. it promoted t cell proliferation, increased nk and lak cell activities as well as anticancer cytokines il-2, il-6, ifn-gamma and tnf-alpha production so as to induce tumor cell apoptosis. celastrol, a triterpene compound isolated from tripterygium wilfordii was proven to be an equally-strong immunosuppressor and inhibited free radical damage in experimental arthritis. ginkgo biloba extract improves cognitive functions. gingkolide a and b inhibited il-1, tnf-alpha and nitric oxide production in rat microglia and prevented the chronic inflammatory process in neurodegenerative diseases.
WOS关键词	NITRIC-OXIDE PRODUCTION ; LIPOPOLYSACCHARIDES IN-VITRO ; CELLS
WOS研究方向	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
WOS类目	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
语种	英语
出版者	INFORMA HEALTHCARE
WOS记录号	WOS:000166795000005
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2376093
专题	武汉病毒研究所
通讯作者	Li, XY
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Li, XY. Immunomodulating components from chinese medicines[J]. Pharmaceutical biology,2000,38:33-40.
APA	Li, XY.(2000).Immunomodulating components from chinese medicines.Pharmaceutical biology,38,33-40.
MLA	Li, XY."Immunomodulating components from chinese medicines".Pharmaceutical biology 38(2000):33-40.

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