| A multinuclear metal complex based dnase-mimetic artificial enzyme: matrix cleavage for combating bacterial biofilms | |
| Chen, Zhaowei1,2,3,4,5; Ji, Haiwei1,2,3; Liu, Chaoqun1,2,3; Bing, Wei1,2,3; Wang, Zhenzhen1,2,3; Qu, Xiaogang1,2 | |
| 刊名 | Angewandte chemie-international edition
 |
| 2016-08-26 | |
| 卷号 | 55期号:36页码:10732-10736 |
| 关键词 | Artificial enzymes Bacteria Biofilms Dnase Extracellular dna |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201605296 |
| 通讯作者 | Qu, xiaogang(xqu@ciac.ac.cn) |
| 英文摘要 | Extracellular dna (edna) is an essential structural component during biofilm formation, including initial bacterial adhesion, subsequent development, and final maturation. herein, the construction of a dnase-mimetic artificial enzyme (dmae) for anti-biofilm applications is described. by confining passivated gold nanoparticles with multiple cerium(iv) complexes on the surface of colloidal magnetic fe3o4/sio2 core/shell particles, a robust and recoverable artificial enzyme with dnase-like activity was obtained, which exhibited high cleavage ability towards both model substrates and edna. compared to the high environmental sensitivity of natural dnase in anti-biofilm applications, dmae exhibited a much better operational stability and easier recoverability. when dmae was coated on substratum surfaces, biofilm formation was inhibited for prolonged periods of time, and the dmae excelled in the dispersion of established biofilms of various ages. finally, the presence of dmae remarkably potentiated the efficiency of traditional antibiotics to kill biofilm-encased bacteria and eradiate biofilms. |
| WOS关键词 | EXTRACELLULAR DNA ; STAPHYLOCOCCUS-EPIDERMIDIS ; GOLD NANOPARTICLES ; PHOSPHATE DIESTERS ; NITRIC-OXIDE ; SURFACE ; ANTIBACTERIAL ; NANOMATERIALS ; HYDROLYSIS ; MECHANISM |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000383473600036 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2376011 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Qu, Xiaogang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Biol Chem Lab, Changchun 130022, Jilin, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resources Utilizat, Changchun 130022, Jilin, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 4.Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Raleigh, NC 27695 USA 5.North Carolina State Univ, Raleigh, NC 27695 USA |
| 推荐引用方式 GB/T 7714 | Chen, Zhaowei,Ji, Haiwei,Liu, Chaoqun,et al. A multinuclear metal complex based dnase-mimetic artificial enzyme: matrix cleavage for combating bacterial biofilms[J]. Angewandte chemie-international edition,2016,55(36):10732-10736. |
| APA | Chen, Zhaowei,Ji, Haiwei,Liu, Chaoqun,Bing, Wei,Wang, Zhenzhen,&Qu, Xiaogang.(2016).A multinuclear metal complex based dnase-mimetic artificial enzyme: matrix cleavage for combating bacterial biofilms.Angewandte chemie-international edition,55(36),10732-10736. |
| MLA | Chen, Zhaowei,et al."A multinuclear metal complex based dnase-mimetic artificial enzyme: matrix cleavage for combating bacterial biofilms".Angewandte chemie-international edition 55.36(2016):10732-10736. |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论