| Superior protection provided by a single dose of mf59-adjuvanted whole inactivated h5n1 influenza vaccine in type 1 diabetic mice | |
| Wu, Jian1; Wang, Fuyan1,2; Fang, Fang1; Zhang, Wenjie5; Chang, Haiyan1; Zheng, Liyun3; Chen, Ze1,3,4 | |
| 刊名 | Archives of virology
 |
| 2011-03-01 | |
| 卷号 | 156期号:3页码:387-395 |
| ISSN号 | 0304-8608 |
| DOI | 10.1007/s00705-010-0860-4 |
| 通讯作者 | Chen, ze(chenze2005@263.net) |
| 英文摘要 | Vaccination is the preferred strategy for the prevention of influenza virus infection. both h5n1 subunit and split vaccines have shown poor immunogenicity in clinical trials thus far. therefore, it is urgent to develop more immunogenic and antigen-sparing h5n1 influenza vaccines as well as safe and effective adjuvants for humans, especially for immunocompromised people such as patients with diabetes mellitus. in this study, the protective effect of an mf59-adjuvanted inactivated whole-virion h5n1 vaccine was investigated in a type 1 diabetic mouse model. mice (both healthy and diabetic) were immunized with a single dose of the inactivated vaccine, alone or adjuvanted with mf59 or al(oh)(3). after four weeks, mice were challenged with a lethal dose of h5n1 virus. antibody responses, survival rates, lung virus titers and body weight changes were tested. the results showed that addition of mf59 or al(oh)(3) to the vaccine enhanced the antibody responses in both healthy mice and diabetic mice, but the mf59-adjuvanted groups showed higher antibody responses than the al(oh)(3)-adjuvanted groups. the addition of mf59 or al(oh)(3) to the vaccine led to a conversion of the immune response from a th1-biased response to an enhanced mixed th1/th2 profile. the mf59-adjuvanted inactivated whole-virion h5n1 vaccine provided superior protection in type 1 diabetic mice to either the vaccine alone or the vaccine adjuvanted with al(oh)(3). |
| WOS关键词 | I RANDOMIZED-TRIAL ; VIRUS-VACCINE ; BALB/C MICE ; HEMAGGLUTININ VACCINE ; RESPIRATORY-TRACT ; CHRONIC DISEASES ; IMMUNE-RESPONSE ; SUBUNIT VACCINE ; A H5N1 ; IMMUNOGENICITY |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| 出版者 | SPRINGER WIEN |
| WOS记录号 | WOS:000287749100003 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375955 |
| 专题 | 武汉病毒研究所 |
| 通讯作者 | Chen, Ze |
| 作者单位 | 1.Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China 2.Cent S Univ, Xiangya Sch Med, Dept Immunol, Changsha 410078, Hunan, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 4.Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China 5.Shanghai Jiaotong Univ Med, Xinhua Hosp, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Jian,Wang, Fuyan,Fang, Fang,et al. Superior protection provided by a single dose of mf59-adjuvanted whole inactivated h5n1 influenza vaccine in type 1 diabetic mice[J]. Archives of virology,2011,156(3):387-395. |
| APA | Wu, Jian.,Wang, Fuyan.,Fang, Fang.,Zhang, Wenjie.,Chang, Haiyan.,...&Chen, Ze.(2011).Superior protection provided by a single dose of mf59-adjuvanted whole inactivated h5n1 influenza vaccine in type 1 diabetic mice.Archives of virology,156(3),387-395. |
| MLA | Wu, Jian,et al."Superior protection provided by a single dose of mf59-adjuvanted whole inactivated h5n1 influenza vaccine in type 1 diabetic mice".Archives of virology 156.3(2011):387-395. |
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