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	Kaposi's sarcoma-associated herpesvirus-encoded lana down-regulates il-22r1 expression through a cis-acting element within the promoter region
	Su, Ling; Liao, Qingjiao; Wu, Yang; Chen, Xulin
刊名	Plos one
	2011-04-22
卷号	6期号:4页码:10
ISSN号	1932-6203
DOI	10.1371/journal.pone.0019106
通讯作者	Su, ling()
英文摘要	Kaposi's sarcoma-associated herpesvirus (kshv) is considered to be a necessary, but not sufficient, causal agent of kaposi's sarcoma (ks). all forms of ks are characterized by the proliferation of spindle-shaped cells, and most (>90%) spindle cells from ks lesions are latently infected with kshv. during kshv latency, only a few viral genes are expressed. among those latent genes, the orf 73 gene encodes the latency-associated nuclear antigen (lana), which is critical for the establishment and maintenance of the latent kshv infection. much evidence suggests that many cytokines can increase the frequency and aggressiveness of ks. in this study, a microarray analysis of ks and normal tissues revealed that multiple cytokines and cytokine receptors are regulated by kshv latent infection. of special interest, il-22r1 transcript level was found to be down-regulated in the ks tissue. to study the possible regulation of il-22r1 by lana, the il-22r1 promoter was constructed and found to contain a lana-binding site (lbs). lana was demonstrated to down-regulate il-22r1 expression via direct binding to the lbs located within the il-22r1 promoter region. furthermore, kshv latently infected cells showed an impaired response to il-22 stimulation. these results suggest that lana can regulate host factor expression by directly binding to a cis-acting element within the factor's promoter to benefit latent viral infection and suppression of the antiviral immune response.
WOS关键词	IMMUNODEFICIENCY-VIRUS TYPE-1 ; ENDOTHELIAL GROWTH-FACTOR ; LYTIC CYCLE REPLICATION ; NUCLEAR ANTIGEN ; GENE-EXPRESSION ; TERMINAL REPEAT ; RECEPTOR COMPLEXES ; RESPONSE ELEMENT ; KINASE PATHWAYS ; CUTTING EDGE
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000290015800043
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375903
专题	武汉病毒研究所
通讯作者	Su, Ling
作者单位	Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Su, Ling,Liao, Qingjiao,Wu, Yang,et al. Kaposi's sarcoma-associated herpesvirus-encoded lana down-regulates il-22r1 expression through a cis-acting element within the promoter region[J]. Plos one,2011,6(4):10.
APA	Su, Ling,Liao, Qingjiao,Wu, Yang,&Chen, Xulin.(2011).Kaposi's sarcoma-associated herpesvirus-encoded lana down-regulates il-22r1 expression through a cis-acting element within the promoter region.Plos one,6(4),10.
MLA	Su, Ling,et al."Kaposi's sarcoma-associated herpesvirus-encoded lana down-regulates il-22r1 expression through a cis-acting element within the promoter region".Plos one 6.4(2011):10.

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