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	Rhesus monkey trim5 alpha has distinct hiv-1 restriction activity among different mammalian cell lines
	Gong, Jian1,2; Shen, Xi-Hui1; Qiu, Hui1; Chen, Chao1; Yang, Rong-Ge1
刊名	Current microbiology
	2011-12-01
卷号	63期号:6页码:531-537
ISSN号	0343-8651
DOI	10.1007/s00284-011-0009-z
通讯作者	Yang, rong-ge(ryang@wh.iov.cn)
英文摘要	Rhesus monkey trim5 alpha (trim5 alpha(rh)), a member of the tripartite motif (trim) family, was identified as the main restriction factor responsible for resistance of old world monkey cells to hiv-1 infection. however, the precise mechanism of hiv-1 infection inhibition by trim5 alpha remains elusive and appears to be related to some cellular cofactors. here we reported that trim5 alpha(rh) can significantly reduce the infection efficiency of vsv-g pseudotyped hiv-1/ma-yfp virus in human epithelial carcinoma (hela) cells, moderately reduce in porcine kidney (pk-15) cells and have no effect on the pseudotyped virus infection in madin-darby canine kidney (mdck) cells. furthermore, we found that the different hiv-1 restriction activities have no relation with the intracellular localization of trim5 alpha(rh). these results indicate that the cellular environment is very important for the efficient anti-hiv-1 activity of trim5 alpha(rh). we speculate that some unknown factors required for hiv-1 infection inhibition activity are adequately expressed in hela cells, inadequately expressed in pk-15 cells and absent in mdck cells.
WOS关键词	RETROVIRUS RESTRICTION ; B-BOX ; DOMAIN ; MOTIF ; TRANSCRIPTION ; DEGRADATION ; PROTEINS ; BINDS ; RING
WOS研究方向	Microbiology
WOS类目	Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000301843400004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375883
专题	武汉病毒研究所
通讯作者	Yang, Rong-Ge
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Huzhou Teachers Coll, Sch Life Sci, Huzhou 313000, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Gong, Jian,Shen, Xi-Hui,Qiu, Hui,et al. Rhesus monkey trim5 alpha has distinct hiv-1 restriction activity among different mammalian cell lines[J]. Current microbiology,2011,63(6):531-537.
APA	Gong, Jian,Shen, Xi-Hui,Qiu, Hui,Chen, Chao,&Yang, Rong-Ge.(2011).Rhesus monkey trim5 alpha has distinct hiv-1 restriction activity among different mammalian cell lines.Current microbiology,63(6),531-537.
MLA	Gong, Jian,et al."Rhesus monkey trim5 alpha has distinct hiv-1 restriction activity among different mammalian cell lines".Current microbiology 63.6(2011):531-537.

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