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	Virucidal activity of a scorpion venom peptide variant mucroporin-m1 against measles, sars-cov and influenza h5n1 viruses
	Li, Qiaoli; Zhao, Zhenhuan2; Zhou, Dihan; Chen, Yaoqing2; Hong, Wei2; Cao, Luyang2; Yang, Jingyi; Zhang, Yan; Shi, Wei; Cao, Zhijian2
刊名	Peptides
	2011-07-01
卷号	32期号:7页码:1518-1525
关键词	Mucroporin-m1 Scorpion venom Measles Sars-cov H5n1 Antiviral
ISSN号	0196-9781
DOI	10.1016/j.peptides.2011.05.015
通讯作者	Yan, huimin(hmyan@wh.iov.cn)
英文摘要	Outbreaks of sars-cov, influenza a (h5n1, h1n1) and measles viruses in recent years have raised serious concerns about the measures available to control emerging and re-emerging infectious viral diseases. effective antiviral agents are lacking that specifically target rna viruses such as measles, sars-cov and influenza h5n1 viruses, and available vaccinations have demonstrated variable efficacy. therefore, the development of novel antiviral agents is needed to close the vaccination gap and silence outbreaks. we previously indentified mucroporin, a cationic host defense peptide from scorpion venom, which can effectively inhibit standard bacteria. the optimized mucroporin-m1 can inhibit gram-positive bacteria at low concentrations and antibiotic-resistant pathogens. in this investigation, we further tested mucroporin and the optimized mucroporin-ml for their antiviral activity. surprisingly, we found that the antiviral activities of mucroporin-m1 against measles, sars-cov and influenza h5n1 viruses were notably increased with an ec(50) of 7.15 mu g/ml (3.52 mu m) and a cc(50) of 70.46 mu g/ml (34.70 mu m) against measles virus, an ec(50) of 14.46 mu g/ml (7.12 mu m) against sars-cov and an ec(50) of 2.10 mu g/ml (1.03 mu m) against h5n1, while the original peptide mucroporin showed no antiviral activity against any of these three viruses. the inhibition model could be via a direct interaction with the virus envelope, thereby decreasing the infectivity of virus. this report provides evidence that host defense peptides from scorpion venom can be modified for antiviral activity by rational design and represents a practical approach for developing broad-spectrum antiviral agents, especially against rna viruses. (c) 2011 elsevier inc. all rights reserved.
WOS关键词	REEMERGING INFECTIOUS-DISEASES ; HERPES-SIMPLEX-VIRUS ; ANTIVIRAL ACTIVITY ; ANTIMICROBIAL PEPTIDES ; IN-VITRO ; VIRAL DISEASES ; HEPATITIS-C ; CORONAVIRUS ; RIBAVIRIN ; INACTIVATION
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000293679200022
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375861
专题	武汉病毒研究所
通讯作者	Yan, Huimin
作者单位	1.Chinese Acad Sci, Mucosal Immun Res Grp, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China
推荐引用方式 GB/T 7714	Li, Qiaoli,Zhao, Zhenhuan,Zhou, Dihan,et al. Virucidal activity of a scorpion venom peptide variant mucroporin-m1 against measles, sars-cov and influenza h5n1 viruses[J]. Peptides,2011,32(7):1518-1525.
APA	Li, Qiaoli.,Zhao, Zhenhuan.,Zhou, Dihan.,Chen, Yaoqing.,Hong, Wei.,...&Li, Wenxin.(2011).Virucidal activity of a scorpion venom peptide variant mucroporin-m1 against measles, sars-cov and influenza h5n1 viruses.Peptides,32(7),1518-1525.
MLA	Li, Qiaoli,et al."Virucidal activity of a scorpion venom peptide variant mucroporin-m1 against measles, sars-cov and influenza h5n1 viruses".Peptides 32.7(2011):1518-1525.

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