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	Amphiphilic polycarbonates from carborane-installed cyclic carbonates as potential agents for boron neutron capture therapy
	Xiong, Hejian1,2; Wei, Xing1,2; Zhou, Dongfang1; Qi, Yanxin1; Xie, Zhigang1; Chen, Xuesi3; Jing, Xiabin1; Huang, Yubin1
刊名	Bioconjugate chemistry
	2016-09-01
卷号	27期号:9页码:2214-2223
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.6b00454
通讯作者	Zhou, dongfang(east@ciac.ac.cn)
英文摘要	Carboranes with rich boron content have showed significant applications in the field of boron neutron capture therapy. biodegradable derivatives of carborane-conjugated polymers with well-defined structure and tunable loading of boron atoms are far less explored. herein, a new family of amphiphilic carborane-conjugated polycarbonates was synthesized by ring-opening polymerization of a carborane-installed cyclic carbonate monomer. catalyzed by tbd from a poly(ethylene glycol) macroinitiator, the polymerization proceeded to relatively high conversions (>65%), with low polydispersity in a certain range of molecular weight. the boron content was readily tuned by the feed ratio of the monomer and initiator. the resultant amphiphilic polycarbonates self-assembled in water into spherical nanoparticles of different sizes depending on the hydrophilic-to hydrophobic ratio. it was demonstrated that larger nanoparticles (pn1.50) were more easily subjected to protein adsorption and captured by the liver, and smaller nanoparticles (pn50) were more likely to enter cancer cells and accumulate at the tumor site. pn50 with thermal neutron irradiation exhibited the highest therapeutic efficacy in vivo. the new synthetic method utilizing amphiphilic biodegradable boron-enriched polymers is useful for developing more-selective and -effective boron delivery systems for bnct.
WOS关键词	POLYMERIC MICELLES ; CLICK CHEMISTRY ; CELLULAR UPTAKE ; DRUG-DELIVERY ; NANOPARTICLES ; SIZE ; CANCER ; TUMOR ; BIODISTRIBUTION ; PHARMACOPHORES
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
WOS类目	Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary ; Chemistry, Organic
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000384036900029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375770
专题	中国科学院大学
通讯作者	Zhou, Dongfang
作者单位	1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China
推荐引用方式 GB/T 7714	Xiong, Hejian,Wei, Xing,Zhou, Dongfang,et al. Amphiphilic polycarbonates from carborane-installed cyclic carbonates as potential agents for boron neutron capture therapy[J]. Bioconjugate chemistry,2016,27(9):2214-2223.
APA	Xiong, Hejian.,Wei, Xing.,Zhou, Dongfang.,Qi, Yanxin.,Xie, Zhigang.,...&Huang, Yubin.(2016).Amphiphilic polycarbonates from carborane-installed cyclic carbonates as potential agents for boron neutron capture therapy.Bioconjugate chemistry,27(9),2214-2223.
MLA	Xiong, Hejian,et al."Amphiphilic polycarbonates from carborane-installed cyclic carbonates as potential agents for boron neutron capture therapy".Bioconjugate chemistry 27.9(2016):2214-2223.

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