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	Ha2 from the helicoverpa armigera nucleopolyhedrovirus: a wasp-related protein that activates arp2/3-induced actin filament formation
	Wang, Qian; Liang, Changyong; Song, Jianhua; Chen, Xinwen
刊名	Virus research
	2007-07-01
卷号	127期号:1页码:81-87
关键词	Baculovirus Helicoverpa armigera nucleopolyhedrovirus Hearnpv Hasnpv Wasp Arp2/3 complex Actin
ISSN号	0168-1702
DOI	10.1016/j.virusres.2007.03.021
通讯作者	Chen, xinwen(chenxw@pentium.whiov.ac.cn)
英文摘要	Filamentous actin is required for the productive replication of lepidopteran nucleopolyhedroviruses. we have demonstrated that nucleocapsids of the helicoverpa armigera nucleopolyhedrovirus (hearnpv) are capable of nucleating actin polymerization in vitro in a dose-dependent manner. actin polymerization is the main mechanism used in cell locomotion and is also utilized by the listeria bacteria and by vaccinia virus for intracellular and intercellular movements. the wasp family of proteins has been shown to stimulate the assembly of branched actin filaments by the arp2/3 complex. the process is conserved in eukaryotic cells. hearnpv orf 2 (ha2), a wasp homologue, could nucleate branched actin filaments in the presence of arp2/3 complex in vitro. we also demonstrate that ha2 co-localizes with arp2/3 complex in the nucleus of infected cells, suggesting that ha2 and arp2/3 complex are involved in nuclear actin polymerization. in summary, ha2 activates arp2/3-induced actin filament network formation in vitro and in vivo. (c) 2007 elsevier b.v. all rights reserved.
WOS关键词	ARP2/3 COMPLEX ; LISTERIA-MONOCYTOGENES ; WASP/SCAR PROTEINS ; ENCODED PROTEIN ; F-ACTIN ; MOTILITY ; POLYMERIZATION ; NUCLEATION ; NETWORKS ; RECONSTITUTION
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000247300900010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375370
专题	武汉病毒研究所
通讯作者	Chen, Xinwen
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qian,Liang, Changyong,Song, Jianhua,et al. Ha2 from the helicoverpa armigera nucleopolyhedrovirus: a wasp-related protein that activates arp2/3-induced actin filament formation[J]. Virus research,2007,127(1):81-87.
APA	Wang, Qian,Liang, Changyong,Song, Jianhua,&Chen, Xinwen.(2007).Ha2 from the helicoverpa armigera nucleopolyhedrovirus: a wasp-related protein that activates arp2/3-induced actin filament formation.Virus research,127(1),81-87.
MLA	Wang, Qian,et al."Ha2 from the helicoverpa armigera nucleopolyhedrovirus: a wasp-related protein that activates arp2/3-induced actin filament formation".Virus research 127.1(2007):81-87.

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