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	Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish
	Chen, Zhenkang1,4; Hu, Yangbo1; Cumming, Bridgette M.2; Lu, Pei1; Feng, Lipeng1; Deng, Jiaoyu1; Steyn, Adrie J. C.2,3; Chen, Shiyun1
刊名	Cell reports
	2016-08-30
卷号	16期号:9页码:2512-2524
ISSN号	2211-1247
DOI	10.1016/j.celrep.2016.07.080
通讯作者	Chen, shiyun(sychen@wh.iov.cn)
英文摘要	During the course of infection, mycobacterium tuberculosis (mtb) is exposed to diverse redox stresses that trigger metabolic and physiological changes. how these stressors are sensed and relayed to the mtb transcriptional apparatus remains unclear. here, we provide evidence that whib6 differentially regulates the esx-1 and dosr regulons through its fe-s cluster. when challenged with no, whib6 continually activates expression of the dosr regulons but regulates esx-1 expression through initial activation followed by gradual inhibition. comparative transcriptomic analysis of the holo-and reduced apo-whib6 complemented strains confirms these results and also reveals that whib6 controls aerobic and anaerobic metabolism, cell division, and virulence. using the mycobacterium marinum zebrafish infection model, we find that holo-and apo-whib6 modulate levels of mycobacterial infection, granuloma formation, and dissemination. these findings provide fresh insight into the role of whib6 in mycobacterial infection, dissemination, and disease development.
WOS关键词	IRON-SULFUR CLUSTER ; NITRIC-OXIDE ; TUBERCULOSIS H37RV ; STRESS CONDITIONS ; GENE-EXPRESSION ; CARBON-MONOXIDE ; BOVIS BCG ; INFECTION ; DORMANCY ; SECRETION
WOS研究方向	Cell Biology
WOS类目	Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000382311300021
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2375337
专题	中国科学院大学
通讯作者	Chen, Shiyun
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, Ctr Emerging Infect Dis, Key Lab Special Pathogens & Biosafety, Wuhan 430071, Peoples R China 2.KwaZulu Natal Res Inst TB & HIV, ZA-4001 Durban, South Africa 3.Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA 4.Univ Chinese Acad Sci, Beijing 10086, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhenkang,Hu, Yangbo,Cumming, Bridgette M.,et al. Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish[J]. Cell reports,2016,16(9):2512-2524.
APA	Chen, Zhenkang.,Hu, Yangbo.,Cumming, Bridgette M..,Lu, Pei.,Feng, Lipeng.,...&Chen, Shiyun.(2016).Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish.Cell reports,16(9),2512-2524.
MLA	Chen, Zhenkang,et al."Mycobacterial whib6 differentially regulates esx-1 and the dos regulon to modulate granuloma formation and virulence in zebrafish".Cell reports 16.9(2016):2512-2524.

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