| Metal-organic-framework-based vaccine platforms for enhanced systemic immune and memory response | |
| Zhang, Yan1,2; Wang, Faming1,2; Ju, Enguo1,2; Liu, Zhen1; Chen, Zhaowei1,2; Ren, Jinsong1; Qu, Xiaogang1 | |
| 刊名 | Advanced functional materials
 |
| 2016-09-01 | |
| 卷号 | 26期号:35页码:6454-6461 |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201600650 |
| 通讯作者 | Ren, jinsong(jren@ciac.ac.cn) ; Qu, xiaogang(xqu@ciac.ac.cn) |
| 英文摘要 | Nanoparticulate delivery platforms have shown promising advantages for vaccines in many aspects. however, their application was limited so far by lengthy synthetic protocols, the requirement of specific modification of antigen, and by the low efficiency in inducing antigen-specific cytotoxic t-lymphocyte responses. this study demonstrates for the first time the construction of metal-organic-framework (mof) based vaccines by encapsulating ovalbumin (ova) and attaching the cytosine-phosphate-guanine oligodeoxynucleotides (cpg odns) in/on zeolitic imidazolate framework-8 (zif-8) nanoparticles. the ph responsive decomposition feature enables the system to release the protein antigens and cpg odns in the same antigen presenting cells more efficiently. more importantly, in addition to the induction of a potent immune memory response, both in vitro and in vivo experiments show that the vaccines can induce strong humoral and cellular immunity. these findings suggest that the mof-based vaccine platforms can be used to produce effective vaccines against a range of ailments, which will facilitate the application of mofs in biomedical areas. |
| WOS关键词 | ONE-POT SYNTHESIS ; ANTIGEN DELIVERY ; CANCER-IMMUNOTHERAPY ; DRUG-DELIVERY ; IMPARTING FUNCTIONALITY ; NANOPARTICLE VACCINES ; CARBON NANOTUBES ; CPG MOTIFS ; DESIGN ; ENCAPSULATION |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000384809100001 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2375043 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ren, Jinsong; Qu, Xiaogang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Biol Chem Lab, Changchun 130022, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yan,Wang, Faming,Ju, Enguo,et al. Metal-organic-framework-based vaccine platforms for enhanced systemic immune and memory response[J]. Advanced functional materials,2016,26(35):6454-6461. |
| APA | Zhang, Yan.,Wang, Faming.,Ju, Enguo.,Liu, Zhen.,Chen, Zhaowei.,...&Qu, Xiaogang.(2016).Metal-organic-framework-based vaccine platforms for enhanced systemic immune and memory response.Advanced functional materials,26(35),6454-6461. |
| MLA | Zhang, Yan,et al."Metal-organic-framework-based vaccine platforms for enhanced systemic immune and memory response".Advanced functional materials 26.35(2016):6454-6461. |
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