| Identification of tra2b-dnah5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma | |
| Li, Fei1,2,3,4; Fang, Zhaoyuan8; Zhang, Jian1,2,3,4; Li, Chen1,2,3; Liu, Hongyan1,2,3; Xia, Jufeng1,2,3; Zhu, Hongwen1,2,3,4; Guo, Chenchen1,2,3,4; Qin, Zhen1,2,3,4; Li, Fuming1,2,3 | |
| 刊名 | Cell research
 |
| 2016-10-01 | |
| 卷号 | 26期号:10页码:1149-1164 |
| 关键词 | Lung squamous cell carcinoma Molecular targeted therapy Exon array analyses Tra2b-dnah5 fusion Selumetinib |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2016.111 |
| 通讯作者 | Ji, hongbin(hbji@sibcb.ac.cn) |
| 英文摘要 | Lung squamous cell carcinoma (scc) is one of the major subtypes of lung cancer. our current knowledge of oncogenic drivers in this specific subtype of lung cancer is largely limited compared with lung adenocarcinoma (adc). through exon array analyses, molecular analyses and functional studies, we here identify the tra2b-dnah5 fusion as a novel oncogenic driver in lung scc. we found that this gene fusion occurs exclusively in lung scc (3.1%, 5/163), but not in lung adc (0/119). through mechanistic studies, we further revealed that this tra2b-dnah5 fusion promotes lung scc malignant progression through regulating a sirt6-erk1/2-mmp1 signaling axis. we show that inhibition of erk1/2 activation using selumetinib efficiently inhibits the growth of lung scc with tra2b-dnah5 fusion expression. these findings improve our current knowledge of oncogenic drivers in lung scc and provide a potential therapeutic strategy for lung scc patients with tra2b-dnah5 fusion. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; RET GENE FUSION ; NEVER-SMOKERS ; MATRIX METALLOPROTEINASE-1 ; SIGNALING PATHWAY ; CANCER ; MUTATIONS ; EXPRESSION ; ADENOCARCINOMA ; SIRT6 |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | INST BIOCHEMISTRY & CELL BIOLOGY |
| WOS记录号 | WOS:000386135200009 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2374974 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Hongbin |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 200120, Peoples R China 6.Fudan Univ, Shanghai Canc Ctr, Dept Thorac Surg, Shanghai 200032, Peoples R China 7.Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 8.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Key Lab Computat Biol, Shanghai 200031, Peoples R China 9.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA |
| 推荐引用方式 GB/T 7714 | Li, Fei,Fang, Zhaoyuan,Zhang, Jian,et al. Identification of tra2b-dnah5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma[J]. Cell research,2016,26(10):1149-1164. |
| APA | Li, Fei.,Fang, Zhaoyuan.,Zhang, Jian.,Li, Chen.,Liu, Hongyan.,...&Ji, Hongbin.(2016).Identification of tra2b-dnah5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma.Cell research,26(10),1149-1164. |
| MLA | Li, Fei,et al."Identification of tra2b-dnah5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma".Cell research 26.10(2016):1149-1164. |
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