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	Amphiphilic brush polymers produced using the raft polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles
	Zhai, Jiali1,2; Suryadinata, Randy2; Luan, Bao3,4,5; Nhiem Tran1,3,6; Hinton, Tracey M.7; Ratcliffe, Julian3; Hao, Xiaojuan3; Drummond, Calum J.1
刊名	Faraday discussions
	2016
卷号	191页码:545-563
ISSN号	1359-6640
DOI	10.1039/c6fd00039h
通讯作者	Drummond, calum j.(calum.drummond@rmit.edu.au)
英文摘要	Self-assembled lipid lyotropic liquid crystalline nanoparticles such as hexosomes and cubosomes contain internal anisotropic and isotropic nanostructures, respectively. despite the remarkable potential of such nanoparticles in various biomedical applications, the stabilisers used in formulating the nanoparticles are often limited to commercially available polymers such as the pluronic block copolymers. this study explored the potential of using reversible addition-fragmentation chain transfer (raft) technology to design amphiphilic brush-type polymers for the purpose of stabilising phytantriol and monoolein-based lipid dispersions. the synthesised brush-type polymers consisted of a hydrophobic c12 short chain and a hydrophilic poly(ethylene glycol) methyl ether acrylate (pega) long chain with multiple 9-unit poly(ethylene oxide) (peo) brushes with various molecular weights. it was observed that increasing the peo brush density and thus the length of the hydrophilic component improved the stabilisation effectiveness for phytantriol and monoolein-based cubosomes. synchrotron small-angle x-ray scattering (saxs) experiments confirmed that the raft polymer-stabilised cubosomes had an internal double-diamond cubic phase with tunable water channel sizes. these properties were dependent on the molecular weight of the polymers, which were considered in some cases to be anisotropically distributed within the cubosomes. the in vitro toxicity of the cubosomes was assessed by cell viability of two human adenocarcinoma cell lines and haemolytic activities to mouse erythrocytes. the results showed that phytantriol cubosomes stabilised by the raft polymers were less toxic compared to their pluronic f127-stabilised analogues. this study provides valuable insight into designing non-linear amphiphilic polymers for the effective stabilisation and cellular toxicity improvement of self-assembled lipid lyotropic liquid crystalline nanoparticles.
WOS关键词	SELF-ASSEMBLED NANOSTRUCTURES ; STERIC STABILIZERS ; DRUG-DELIVERY ; CUBIC PHASES ; CUBOSOME FORMULATIONS ; ETHER ACRYLATE) ; HELA-CELLS ; X-RAY ; PARTICLES ; DISPERSIONS
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000385257300030
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374853
专题	中国科学院大学
通讯作者	Drummond, Calum J.
作者单位	1.RMIT Univ, Coll Sci Engn & Hlth, Sch Sci, POB 2476, Melbourne, Vic 3001, Australia 2.CSIRO Mfg, 343 Royal Parade, Parkville, Vic 3052, Australia 3.CSIRO Mfg, Private Bag 10, Clayton, Vic 3169, Australia 4.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 5.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 6.Australian Synchrotron, 800 Blackburn Rd, Clayton, Vic 3168, Australia 7.CSIRO Biosecur, Australian Anim Hlth Lab, 5 Portarlington Rd, East Geelong, Vic 3129, Australia
推荐引用方式 GB/T 7714	Zhai, Jiali,Suryadinata, Randy,Luan, Bao,et al. Amphiphilic brush polymers produced using the raft polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles[J]. Faraday discussions,2016,191:545-563.
APA	Zhai, Jiali.,Suryadinata, Randy.,Luan, Bao.,Nhiem Tran.,Hinton, Tracey M..,...&Drummond, Calum J..(2016).Amphiphilic brush polymers produced using the raft polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles.Faraday discussions,191,545-563.
MLA	Zhai, Jiali,et al."Amphiphilic brush polymers produced using the raft polymerisation method stabilise and reduce the cell cytotoxicity of lipid lyotropic liquid crystalline nanoparticles".Faraday discussions 191(2016):545-563.

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