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	The camsap3-acf7 complex couples noncentrosomal microtubules with actin filaments to coordinate their dynamics
	Ning, Wenxiu1,2; Yu, Yanan1,2; Xu, Honglin1; Liu, Xiaofei1,2; Wang, Daiwei1,2; Wang, Jing1; Wang, Yingchun1,2; Meng, Wenxiang1,2
刊名	Developmental cell
	2016-10-10
卷号	39期号:1页码:61-74
ISSN号	1534-5807
DOI	10.1016/j.devcel.2016.09.003
通讯作者	Meng, wenxiang(wxmeng@genetics.ac.cn)
英文摘要	For adaptation to complex cellular functions, dynamic cytoskeletal networks are required. there are two major components of the cytoskeleton, microtubules and actin filaments, which form an intricate network maintaining an exquisite cooperation to build the physical basis for their cellular function. however, little is known about the molecular mechanism underlying their synergism. here, we show that in caco2 epithelial cells, noncentrosomal microtubules crosstalk with f-actin through their minus ends and contribute to the regulation of focal adhesion size and cell migration. we demonstrate that acf7, a member of the spectraplakin family of cytoskeletal crosslinking proteins, interacts with nezha (also called camsap3) at the minus ends of noncentrosomal microtubules and anchors them to actin filaments. those noncentrosomal microtubules cooperate with actin filaments through retrograde flow to keep their length and orientation perpendicular to the cell edge as well as regulate focal adhesion size and cell migration.
WOS关键词	FOCAL ADHESION DYNAMICS ; MIGRATING CELLS ; GROWTH CONE ; MINUS ENDS ; KINASE ; MUSCLE ; ACF7 ; JUNCTIONS ; PATRONIN ; PROTEIN
WOS研究方向	Cell Biology ; Developmental Biology
WOS类目	Cell Biology ; Developmental Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000385471100010
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374832
专题	中国科学院大学
通讯作者	Meng, Wenxiang
作者单位	1.Chinese Acad Sci, State Key Lab Mol Dev Biol, Inst Genet & Dev Biol, 3 Zhongguancun South Rd, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Ning, Wenxiu,Yu, Yanan,Xu, Honglin,et al. The camsap3-acf7 complex couples noncentrosomal microtubules with actin filaments to coordinate their dynamics[J]. Developmental cell,2016,39(1):61-74.
APA	Ning, Wenxiu.,Yu, Yanan.,Xu, Honglin.,Liu, Xiaofei.,Wang, Daiwei.,...&Meng, Wenxiang.(2016).The camsap3-acf7 complex couples noncentrosomal microtubules with actin filaments to coordinate their dynamics.Developmental cell,39(1),61-74.
MLA	Ning, Wenxiu,et al."The camsap3-acf7 complex couples noncentrosomal microtubules with actin filaments to coordinate their dynamics".Developmental cell 39.1(2016):61-74.

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