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	The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis
	Hussain, Muzammil1,2; Hamid, M. Imran1,3; Wang, Niuniu1,2; Bin, Lin1,2; Xiang, Meichun1; Liu, Xingzhong1
刊名	Scientific reports
	2016-07-20
卷号	6页码:12
ISSN号	2045-2322
DOI	10.1038/srep30047
通讯作者	Xiang, meichun(xiangmc@im.ac.cn) ; Liu, xingzhong(liuxz@im.ac.cn)
英文摘要	The transcription factor skn7 is a highly conserved protein among fungi and was initially recognized as a response regulator that protects cells from oxidative stress and maintains cell wall integrity in yeast. orthologs of skn7 are extensively present in biocontrol agents of plant pathogens, but they had not been functionally characterized. here, we identified and characterized the transcription factor skn7 in the nematode endoparasitic fungus hirsutella minnesotensis. null mutant lacking him-skn7 (him_03620), which was generated by a gene disruption strategy, demonstrated reduced conidiation, increased sensitivity to high temperature, hydrogen peroxide, mannitol and ethanol, and reduced fungal resistance to farnesol. however, over-expression mutant showed increased conidial production, thermotolerance and resistance to farnesol, suggesting that him-skn7 regulates antiapoptotic-like cell death in h. minnesotensis. moreover, the results showed that in null mutant, h. minnesotensis had decreased endoparasitic ability as compared to wild type and over-expression strain. during the infection process, the relative expression of the him-skn7 gene was significantly induced in the wild type and over-expression strain. the results of the present study advance our understanding of the functions of the skn7 gene in biocontrol agents, in particular, nematode endoparasitic fungi.
WOS关键词	2-COMPONENT SIGNAL TRANSDUCERS ; HEAT-SHOCK PROTEINS ; SACCHAROMYCES-CEREVISIAE ; CONIOTHYRIUM-MINITANS ; HETERODERA-GLYCINES ; RESPONSE REGULATOR ; OXIDATIVE STRESS ; GENE-EXPRESSION ; SOYBEAN FIELDS ; BUDDING YEAST
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000379920900001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374673
专题	中国科学院大学
通讯作者	Xiang, Meichun; Liu, Xingzhong
作者单位	1.Chinese Acad Sci, Inst Microbiol, State Key Lab Mycol, 3 Pk 1,Beichen West Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Sargodha, Univ Coll Agr, Dept Plant Pathol, Sargodha 40100, Pakistan
推荐引用方式 GB/T 7714	Hussain, Muzammil,Hamid, M. Imran,Wang, Niuniu,et al. The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis[J]. Scientific reports,2016,6:12.
APA	Hussain, Muzammil,Hamid, M. Imran,Wang, Niuniu,Bin, Lin,Xiang, Meichun,&Liu, Xingzhong.(2016).The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis.Scientific reports,6,12.
MLA	Hussain, Muzammil,et al."The transcription factor skn7 regulates conidiation, thermotolerance, apoptotic-like cell death and parasitism in the nematode endoparasitic fungus hirsutella minnesotensis".Scientific reports 6(2016):12.

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