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	Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection
	Chen, Zhuo1,2; Zhang, Yaxin1,2,3; Wang, Dong1,2,3; Li, Linsen4; Zhou, Shanyong1; Huang, Joy H.1; Chen, Jincan1; Hu, Ping1; Huang, Mingdong1,2
刊名	Journal of biomedical optics
	2016
卷号	21期号:1页码:7
关键词	Photodynamic antimicrobial chemotherapy Zinc phthalocyanine Bacterial infection Skin Propionibacterium acnes Staphylococcus aureus
ISSN号	1083-3668
DOI	10.1117/1.jbo.21.1.018001
通讯作者	Chen, zhuo(zchen@fjirsm.ac.cn) ; Huang, mingdong(mhuang@fjirsm.ac.cn)
英文摘要	Photodynamic antimicrobial chemotherapy (pact) is an effective method for killing bacterial cells in view of the increasing problem of multiantibiotic resistance. we herein reported the pact effect on bacteria involved in skin infections using a zinc phthalocyanine derivative, pentalysine beta-carbonylphthalocyanine zinc (znpc-(lys)(5)). compared with its anionic znpc counterpart, znpc-(lys)(5) showed an enhanced antibacterial efficacy in vitro and in an animal model of localized infection. meanwhile, znpc-(lys)(5) was observed to significantly reduce the wound skin blood flow during wound healing, indicating an anti-inflammation activity. this study provides new insight on the mechanisms of pact in bacterial skin infection. (c) 2016 society of photo-optical instrumentation engineers (spie)
WOS关键词	STAPHYLOCOCCUS-AUREUS ; THERAPY ; PEPTIDES ; STRAINS ; AGENTS ; MODEL
WOS研究方向	Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
WOS记录号	WOS:000380036500029
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374551
专题	中国科学院大学
通讯作者	Chen, Zhuo; Huang, Mingdong
作者单位	1.Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, 155 West Yangqiao Rd, Fuzhou 350002, Fujian, Peoples R China 2.Chinese Acad Sci, Grad Univ, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Fujian Normal Univ, 1 Keji Rd, Fuzhou 350117, Fujian, Peoples R China 4.Shenyang Med Coll, 146 North Huanghe Main St, Shenyang 110034, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zhuo,Zhang, Yaxin,Wang, Dong,et al. Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection[J]. Journal of biomedical optics,2016,21(1):7.
APA	Chen, Zhuo.,Zhang, Yaxin.,Wang, Dong.,Li, Linsen.,Zhou, Shanyong.,...&Huang, Mingdong.(2016).Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection.Journal of biomedical optics,21(1),7.
MLA	Chen, Zhuo,et al."Photodynamic antimicrobial chemotherapy using zinc phthalocyanine derivatives in treatment of bacterial skin infection".Journal of biomedical optics 21.1(2016):7.

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