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	Associations between variants on adipoq and adipor1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis
	Ou,Yiyi1,2; Chen,Peizhan1; Zhou,Ziyuan3,4; Li,Chenglin1; Liu,Jinyi3; Tajima,Kazuo5; Guo,Junsheng6; Cao,Jia3; Wang,Hui1,7,8
刊名	Bmc medical genetics
	2014-12-17
卷号	15期号:1
关键词	Adipoq Adipor1 Colorectal cancer Meta-analysis
ISSN号	1471-2350
DOI	10.1186/s12881-014-0137-y
通讯作者	Guo,junsheng(guojs@shhyy.com) ; Cao,jia(caojia@mail.tmmu.com.cn) ; Wang,hui(huiwang@sibs.ac.cn)
英文摘要	Abstractbackgroundepidemiological studies have suggested that variants on adiponectin (adipoq) and its receptor adipor1 (adiponectin receptor 1) are associated with colorectal cancer (crc) risk; however, the results were inconclusive. the aim of the study was to evaluate the associations between the variants on adipoq and adipor1 and the crc risk with a hospital-based case-control study in the chinese population along with meta-analysis of available epidemiological studies.methodswith a hospital-based case-control study of 341 cases and 727 controls, the associations between the common variants on adipoq (rs266729, rs822395, rs2241766 and rs1501299) and adipor1 (rs1342387 and rs12733285) and crc susceptibility were evaluated. meta-analysis of the published epidemiological studies was performed to investigate the associations between the variants and crc risk.resultsfor the population study, we found that variant rs1342387 of adipor1 was associated with a reduced risk for crc [adjusted odds ratio (or)?=?0.74, 95% confidential intervals (95% ci)?=?0.57-0.97; ct/tt vs. cc]. the meta-analysis also suggested a significant association for rs1342387 and crc risk; the pooled or was 0.79 (95% ci?=?0.66-0.95) for the ct/tt carriers compared to cc homozygotes under the random-effects model (q?=?8.06, df?=?4, p?=?0.089; i2?=?50.4%). the case-control study found no significant association for variants rs266729, rs822395, rs2241766, and rs1501299 on adipoq or variant rs12733285 on adipor1 and crc susceptibility, which were consistent with results from the meta-analysis studies.conclusionsthese data suggested that variant rs1342387 on adipor1 may be a novel crc susceptibility factor.
语种	英语
出版者	BioMed Central
WOS记录号	BMC:10.1186/S12881-014-0137-Y
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374318
专题	中国科学院大学
通讯作者	Guo,Junsheng; Cao,Jia; Wang,Hui
作者单位	1.University of Chinese Academy of Sciences; Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 2.The General Hospital of Navy; Medical Department 3.College of Preventive Medicine; Third Military Medical University; Toxicology Institute, Key Lab of Medical Protection for Electromagnetic Radiation, Ministry of Education of China 4.College of Preventive Medicine; Third Military Medical University; Department of Environment Health 5.Aichi Cancer Center Research Institute; Division of Epidemiology and Prevention 6.Second Military Medical University; Department of Military Hygiene, Faculty of Naval Medicine 7.Ministry of Health; Key Laboratory of Food Safety Risk Assessment 8.ShanghaiTech University; School of Life Science and Technology
推荐引用方式 GB/T 7714	Ou,Yiyi,Chen,Peizhan,Zhou,Ziyuan,et al. Associations between variants on adipoq and adipor1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis[J]. Bmc medical genetics,2014,15(1).
APA	Ou,Yiyi.,Chen,Peizhan.,Zhou,Ziyuan.,Li,Chenglin.,Liu,Jinyi.,...&Wang,Hui.(2014).Associations between variants on adipoq and adipor1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis.Bmc medical genetics,15(1).
MLA	Ou,Yiyi,et al."Associations between variants on adipoq and adipor1 with colorectal cancer risk: a chinese case-control study and updated meta-analysis".Bmc medical genetics 15.1(2014).

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