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	Kdm2b regulates somatic reprogramming through variant prc1 complex-dependent function
	Zhou, Zhiwei1,2,3,4; Yang, Xuejie1,2,3,4; He, Jiangping1,2,3,4,5; Liu, Jing1,2,3; Wu, Fang1,2,3,4; Yu, Shengyong1,2,3; Liu, Yuting1,2,3; Lin, Runxia1,2,3,4; Liu, He1,2,3,4; Cui, Yuanbin1,2,4,6
刊名	Cell reports
	2017-11-21
卷号	21期号:8页码:2160-2170
ISSN号	2211-1247
DOI	10.1016/j.celrep.2017.10.091
通讯作者	Pei, duanqing(pei_duanqing@gibh.ac.cn) ; Chen, jiekai(chen_jiekai@gibh.ac.cn)
英文摘要	Polycomb repressive complex 1 (prc1) plays essential roles in cell-fate determination. recent studies have found that the composition of mammalian prc1 is particularly varied and complex; however, little is known about the functional consequences of these variant prc1 complexes on cell-fate determination. here, we show that kdm2b promotes oct4-induced somatic reprogramming through recruitment of a variant prc1 complex (prc1.1) to cpg islands (cgis). furthermore, we find that bone morphogenetic protein (bmp) represses oct4/kdm2b-induced somatic reprogramming selectively. mechanistically, bmp-smad pathway attenuates prc1.1 occupation and h2ak119 ubiquitination at genes linked to development, resulting in the expression of mesendodermal factors such as sox17 and a consequent suppression of somatic reprogramming. these observations reveal that prc1.1 participates in the establishment of pluripotency and identify bmp4 signaling as a modulator of prc1.1 function.
WOS关键词	EMBRYONIC STEM-CELLS ; H2A UBIQUITYLATION ; CPG ISLANDS ; HISTONE H3 ; POLYCOMB ; PROTEINS ; FAMILY ; GENES ; RYBP ; DEMETHYLATION
WOS研究方向	Cell Biology
WOS类目	Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000416216700013
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2374237
专题	计算机网络信息中心
通讯作者	Pei, Duanqing; Chen, Jiekai
作者单位	1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, CAS Key Lab Regenerat Biol, Guangzhou, Guangdong, Peoples R China 2.Guangzhou Med Univ, Guangzhou, Guangdong, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Guangdong, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Guangzhou Branch, Supercomp Ctr, Guangzhou 510530, Guangdong, Peoples R China 6.South China Univ Technol, Sch Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China 7.Chinese Acad Med Sci, Inst Basic Med Sci,Sch Basic Med, Peking Union Med Coll,Med Primate Res Ctr,Neurosc, State Key Lab Med Mol Biol,Dept Mol Biol & Bioche, Beijing 100005, Peoples R China 8.Southern Univ Sci & Technol China, Dept Biol, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Zhiwei,Yang, Xuejie,He, Jiangping,et al. Kdm2b regulates somatic reprogramming through variant prc1 complex-dependent function[J]. Cell reports,2017,21(8):2160-2170.
APA	Zhou, Zhiwei.,Yang, Xuejie.,He, Jiangping.,Liu, Jing.,Wu, Fang.,...&Chen, Jiekai.(2017).Kdm2b regulates somatic reprogramming through variant prc1 complex-dependent function.Cell reports,21(8),2160-2170.
MLA	Zhou, Zhiwei,et al."Kdm2b regulates somatic reprogramming through variant prc1 complex-dependent function".Cell reports 21.8(2017):2160-2170.

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