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	Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from hubei province, china
	Zhang, Yanfang1; Shen, Shu1; Shi, Junming1; Su, Zhengyuan1; Li, Mingyue2; Zhang, Wenjing2; Li, Mengmeng2; Hu, Zhihong1; Peng, Cheng2; Zheng, Xin2
刊名	Virologica sinica
	2017-02-01
卷号	32期号:1页码:89-96
关键词	Bunyavirus Severe fever with thrombocytopenia syndrome bunyavirus (sftsv) Isolation Phylogenetic analysis Genotype
ISSN号	1674-0769
DOI	10.1007/s12250-017-3953-3
通讯作者	Zheng, xin(xin11@hotmail.com) ; Deng, fei(df@wh.iov.cn)
英文摘要	Hubei province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus (sftsv) in china. however, to date, a few sftsv strains have been isolated from hubei province, preventing effective studies of epidemic outbreaks. here, we report three confirmed patients (2015-2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease (sfts) who were farmers resident in different regions in hubei province. three new sftsv strains were isolated from the serum samples of each patient. characterization of viral growth properties showed that there were no significant differences in virus production. all strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from hubei province, which belonged to the sftsv c3 genotype, one of the three strains belonged to the sftsv c2 genotype. these results suggested that multiple sftsv genotypes have been circulating in hubei province, providing insights into sftsv evolution and improving our understanding of sftsv prevalence in hubei province.
WOS关键词	SYNDROME VIRUS ; MODEL
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000396155400011
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373454
专题	武汉病毒研究所
通讯作者	Zheng, Xin; Deng, Fei
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Infect Dis,Inst Infect & Immunol, Wuhan 430022, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yanfang,Shen, Shu,Shi, Junming,et al. Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from hubei province, china[J]. Virologica sinica,2017,32(1):89-96.
APA	Zhang, Yanfang.,Shen, Shu.,Shi, Junming.,Su, Zhengyuan.,Li, Mingyue.,...&Deng, Fei.(2017).Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from hubei province, china.Virologica sinica,32(1),89-96.
MLA	Zhang, Yanfang,et al."Isolation, characterization, and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from hubei province, china".Virologica sinica 32.1(2017):89-96.

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