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	Pkacs attenuate innate antiviral response by phosphorylating visa and priming it for march5-mediated degradation
	Yan, Bing-Ru1,2; Zhou, Lu1,2; Hu, Ming-Ming2; Li, Mi1,2; Lin, Heng1,2; Yang, Yan3; Wang, Yan-Yi3; Shu, Hong-Bing1,2
刊名	Plos pathogens
	2017-09-01
卷号	13期号:9页码:20
ISSN号	1553-7366
DOI	10.1371/journal.ppat.1006648
通讯作者	Shu, hong-bing(shuh@whu.edu.cn)
英文摘要	Sensing of viral rna by rig-i-like receptors initiates innate antiviral response, which is mediated by the central adaptor visa. how the rig-i-visa-mediated antiviral response is terminated at the late phase of infection is enigmatic. here we identified the protein kinase a catalytic (pkac) subunits a and beta as negative regulators of rna virus-triggered signaling in a redundant manner. viral infection up-regulated cellular camp levels and activated pkacs, which then phosphorylated visa at t54. this phosphorylation abrogated virus-induced aggregation of visa and primed it for k48-linked polyubiquitination and degradation by the e3 ligase march5, leading to attenuation of virus-triggered induction of downstream antiviral genes. pkacs-deficiency or inactivation by the inhibitor h89 potentiated innate immunity to rna viruses in cells and mice. our findings reveal a critical mechanism of attenuating innate immune response to avoid host damage at the late phase of viral infection by the house-keeping pka kinase.
WOS关键词	NF-KAPPA-B ; PROTEIN-KINASE-A ; I-LIKE RECEPTORS ; RIG-I ; IMMUNE-RESPONSE ; ADAPTER PROTEIN ; TRANSCRIPTIONAL ACTIVITY ; SIGNALING ADAPTER ; CATALYTIC SUBUNIT ; DNA VIRUS
WOS研究方向	Microbiology ; Parasitology ; Virology
WOS类目	Microbiology ; Parasitology ; Virology
语种	英语
出版者	PUBLIC LIBRARY SCIENCE
WOS记录号	WOS:000411968300051
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373394
专题	武汉病毒研究所
通讯作者	Shu, Hong-Bing
作者单位	1.Wuhan Univ, Coll Life Sci, Wuhan, Hubei, Peoples R China 2.Wuhan Univ, Med Res Inst, Sch Med, Wuhan, Hubei, Peoples R China 3.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Yan, Bing-Ru,Zhou, Lu,Hu, Ming-Ming,et al. Pkacs attenuate innate antiviral response by phosphorylating visa and priming it for march5-mediated degradation[J]. Plos pathogens,2017,13(9):20.
APA	Yan, Bing-Ru.,Zhou, Lu.,Hu, Ming-Ming.,Li, Mi.,Lin, Heng.,...&Shu, Hong-Bing.(2017).Pkacs attenuate innate antiviral response by phosphorylating visa and priming it for march5-mediated degradation.Plos pathogens,13(9),20.
MLA	Yan, Bing-Ru,et al."Pkacs attenuate innate antiviral response by phosphorylating visa and priming it for march5-mediated degradation".Plos pathogens 13.9(2017):20.

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