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	Japanese encephalitis virus counteracts bst2 restriction via its envelope protein e
	Li, Mei1,2; Wang, Ping1,2; Zheng, Zifeng1,2; Hu, Kai1; Zhang, Mudan1; Guan, Xinmeng1,2; Fu, Ming1,2; Zhang, Di1,2; Wang, Wei1; Xiao, Gengfu1
刊名	Virology
	2017-10-01
卷号	510页码:67-75
关键词	Jev Bst2 Restriction Envelope protein e Antagonism
ISSN号	0042-6822
DOI	10.1016/j.viro1.2017.07.008
通讯作者	Hu, qinxue(qhu@wh.iov.cn) ; Liu, yalan(liuyl@wh.iov.cn)
英文摘要	It has b een well documented that bst2 restricts the release of enveloped viruses by cross-linking newly produced virions to the cell membrane. however, it is less clear whether and how bst2 inhibits the release of enveloped viruses which bud via the secretory pathway. here, we demonstrated that bst2 restricts the release of japanese encephalitis virus (jev) whose budding occurs at the er-golgi intermediate compartment, and in turn, jev infection downregulates bst2 expression. we further found that the jev envelope protein e, but not other viral components, significantly downregulates bst2 with the viral protein m playing an auxiliary role in the process. envelope protein e-mediated bst2 downregulation appears to undergo lysosomal degradation pathway. additional study revealed that the transmembrane domain and the coiled-coil domain (cc) of bst2 are the target domains of viral protein e and that the n- and c-terminal membrane anchors and the cc domain of bst2 are essential for blocking jev release. our results together indicate that the release of enveloped viruses whose budding take place in an intracellular compartment can be restricted by bst2.
WOS关键词	TETHERING VIRIONS ; RELEASE ; BST-2/TETHERIN ; INFECTION ; GLYCOPROTEINS ; MECHANISM ; CELLS ; VPU
WOS研究方向	Virology
WOS类目	Virology
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000408400100009
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373378
专题	武汉病毒研究所
通讯作者	Hu, Qinxue; Liu, Yalan
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England
推荐引用方式 GB/T 7714	Li, Mei,Wang, Ping,Zheng, Zifeng,et al. Japanese encephalitis virus counteracts bst2 restriction via its envelope protein e[J]. Virology,2017,510:67-75.
APA	Li, Mei.,Wang, Ping.,Zheng, Zifeng.,Hu, Kai.,Zhang, Mudan.,...&Liu, Yalan.(2017).Japanese encephalitis virus counteracts bst2 restriction via its envelope protein e.Virology,510,67-75.
MLA	Li, Mei,et al."Japanese encephalitis virus counteracts bst2 restriction via its envelope protein e".Virology 510(2017):67-75.

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