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	A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and heartland virus, is a potential pathogen
	Shen, Shu1; Duan, Xiaomei2; Wang, Bo1; Zhu, Liying1; Zhang, Yanfang1; Zhang, Jingyuan2; Wang, Jun1; Luo, Tao3; Kou, Chun2; Liu, Dan4
刊名	Emerging microbes & infections
	2018-05-25
卷号	7页码:14
ISSN号	2222-1751
DOI	10.1038/s41426-018-0093-2
通讯作者	Zhang, yujiang(xjsyzhang@163.com) ; Sun, surong(sr_sun2005@163.com) ; Deng, fei(df@wh.iov.cn)
英文摘要	Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. severe fever with thrombocytopenia syndrome phlebovirus (sftsv) and heartland virus (hrtv) were recently identified as tick-borne phleboviruses (tbpvs) in asia and the united states, respectively, and are associated with severe human diseases with similar clinical manifestations. in this study, we report the first identification and isolation of a novel tbpv named guertu virus (gtv) from dermacentor nuttalli ticks in xinjiang province, china, where tbpvs had not been previously discovered. genome sequence and phylogenetic analyses showed that gtv is closely related to sftsv and hrtv and was classified as a member of the genus phlebovirus, family phenuiviridae, order bunyavirales. in vitro and in vivo investigations of the properties of gtv demonstrated that it was able to infect animal and human cell lines and can suppress type i interferon signaling, similar to sftsv, that gtv nucleoprotein (np) can rescue sftsv replication by replacing sftsv np, and that gtv infection can cause pathological lesions in mice. moreover, a serological survey identified antibodies against gtv from serum samples of individuals living in guertu county, three of which contained neutralizing antibodies, suggesting that gtv can infect humans. our findings suggested that this virus is a potential pathogen that poses a threat to animals and humans. further studies and surveillance of gtv are recommended to be carried out in xinjiang province as well as in other locations.
WOS关键词	REVERSE GENETICS SYSTEM ; SYNDROME BUNYAVIRUS ; SOUTH-KOREA ; MOUSE MODEL ; NONSTRUCTURAL PROTEIN ; MOLECULAR-DETECTION ; HEMORRHAGIC-FEVER ; GENUS PHLEBOVIRUS ; CHINA ; INFECTION
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000434351300001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373265
专题	武汉病毒研究所
通讯作者	Zhang, Yujiang; Sun, Surong; Deng, Fei
作者单位	1.Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China 2.Xinjiang Univ, Coll Life Sci & Technol, Xinjiang Key Lab Biol Resources & Genet Engn, Urumqi 830046, Peoples R China 3.Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830001, Peoples R China 4.Wuhan Univ Sci & Technol, Sch Med, Wuhan 430065, Hubei, Peoples R China 5.Hubei Univ, Coll Life Sci, Hubei Key Lab Ind Biotechnol, Hubei Collaborat Innovat Ctr Green Transformat Bi, Wuhan 430061, Peoples R China
推荐引用方式 GB/T 7714	Shen, Shu,Duan, Xiaomei,Wang, Bo,et al. A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and heartland virus, is a potential pathogen[J]. Emerging microbes & infections,2018,7:14.
APA	Shen, Shu.,Duan, Xiaomei.,Wang, Bo.,Zhu, Liying.,Zhang, Yanfang.,...&Deng, Fei.(2018).A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and heartland virus, is a potential pathogen.Emerging microbes & infections,7,14.
MLA	Shen, Shu,et al."A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and heartland virus, is a potential pathogen".Emerging microbes & infections 7(2018):14.

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