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	Comparing lethal dose ratios using probit regression with arbitrary slopes
	Lei, Chengfeng; Sun, Xiulian
刊名	Bmc pharmacology & toxicology
	2018-10-05
卷号	19页码:10
关键词	Toxicity Probit regression Lethal dose ratio Maximum likelihood
ISSN号	2050-6511
DOI	10.1186/s40360-018-0250-1
通讯作者	Sun, xiulian(sunxl@wh.iov.cn)
英文摘要	Background: evaluating the toxicity or effectiveness of two or more toxicants in a specific population often requires specialized statistical software to calculate and compare median lethal doses (ld(50)s). tests for equality of ld(50)s using probit regression with parallel slopes have been implemented in many software packages, while tests for cases of arbitrary slopes are not generally available. methods: in this study, we established probit-log(dose) regression models and solved them by the maximum likelihood method using microsoft excel. the z- and chi(2)-tests were used to assess significance and goodness of fit to the probit regression models, respectively. we calculated the lethal doses (lds) of the toxicants at different significance levels and their 95% confidence limits (cls) based on an accurate estimation of log(ld) variances. we further calculated lethal dose ratios and their 95% cls for two examples without assuming parallel slopes following the method described by robertson, et al., 2017. results: we selected representative toxicology datasets from the literature as case studies. for datasets without natural responses in the control group, the slopes, intercepts, chi(2) statistics and lds calculated using our method were identical to those calculated using polo-plus and spss software, and the 95% cls of the lethal dose ratios between toxicants were close to those calculated using polo-plus. for datasets that included natural responses in the control group, our results were also close to those calculated using polo-plus and spss. conclusion: this procedure yielded accurate estimates of lethal doses and 95% cls at different significance levels as well as the lethal dose ratios and 95% cls between two examples. the procedure could be used to assess differences in the toxicities of two examples without the assumption of parallelism between probit-log(dose) regression lines.
WOS关键词	INSECTICIDE
WOS研究方向	Pharmacology & Pharmacy ; Toxicology
WOS类目	Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	BMC
WOS记录号	WOS:000446513900001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2373235
专题	武汉病毒研究所
通讯作者	Sun, Xiulian
作者单位	Chinese Acad Sci, Wuhan Inst Virol, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Lei, Chengfeng,Sun, Xiulian. Comparing lethal dose ratios using probit regression with arbitrary slopes[J]. Bmc pharmacology & toxicology,2018,19:10.
APA	Lei, Chengfeng,&Sun, Xiulian.(2018).Comparing lethal dose ratios using probit regression with arbitrary slopes.Bmc pharmacology & toxicology,19,10.
MLA	Lei, Chengfeng,et al."Comparing lethal dose ratios using probit regression with arbitrary slopes".Bmc pharmacology & toxicology 19(2018):10.

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