| Simplified intestinal microbiota to study microbe-diet-host interactions in a mouse model | |
| Kovatcheva-Datchary, Petia1,6; Shoaie, Saeed2; Lee, Sunjae2; Wahlstrom, Annika1; Nookaew, Intawat3,7; Hallen, Anna1; Perkins, Rosie1; Nielsen, Jens3,4; Backhed, Fredrik1,5 | |
| 刊名 | Cell reports
 |
| 2019-03-26 | |
| 卷号 | 26期号:13页码:3772-+ |
| ISSN号 | 2211-1247 |
| DOI | 10.1016/j.celrep.2019.02.090 |
| 通讯作者 | Backhed, fredrik(fredrik.backhed@wlab.gu.se) |
| 英文摘要 | The gut microbiota can modulate human metabolism through interactions with macronutrients. however, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. to reduce the complexity, we colonize mice with a simplified intestinal microbiota (sim) composed of ten sequenced strains isolated from the human gut with complementing pathways to metabolize dietary fibers. we feed the sim mice one of three diets (chow [fiber rich], high-fat/high-sucrose, or zero-fat/high-sucrose diets [both low in fiber]) and investigate (1) how dietary fiber, saturated fat, and sucrose affect the abundance and transcriptome of the sim community, (2) the effect of microbe-diet interactions on circulating metabolites, and (3) how microbiota-diet interactions affect host metabolism. our sim model can be used in future studies to help clarify how microbiota-diet interactions contribute to metabolic diseases. |
| WOS关键词 | BUTYRATE-PRODUCING BACTERIA ; HUMAN COLONIC MICROBIOTA ; GUT MICROBIOTA ; SP NOV. ; AKKERMANSIA-MUCINIPHILA ; GENE-EXPRESSION ; IDENTIFICATION ; FERMENTATION ; PROPOSAL ; FIBER |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000462490900026 |
| 内容类型 | 期刊论文 |
| URI标识 | http://www.corc.org.cn/handle/1471x/2372662 |
| 专题 | 大连化学物理研究所 |
| 通讯作者 | Backhed, Fredrik |
| 作者单位 | 1.Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden 2.Kings Coll London, Ctr Host Microbiome Interact, Dent Inst, London SE1 9RT, England 3.Chalmers Univ Technol, Dept Biol & Biol Engn, S-41345 Gothenburg, Sweden 4.Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark 5.Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Receptol & Enteroendocrinol, DK-2200 Copenhagen, Denmark 6.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 7.Univ Arkansas Med Sci, Coll Med, Dept Biomed Informat, Little Rock, AR 72205 USA |
| 推荐引用方式 GB/T 7714 | Kovatcheva-Datchary, Petia,Shoaie, Saeed,Lee, Sunjae,et al. Simplified intestinal microbiota to study microbe-diet-host interactions in a mouse model[J]. Cell reports,2019,26(13):3772-+. |
| APA | Kovatcheva-Datchary, Petia.,Shoaie, Saeed.,Lee, Sunjae.,Wahlstrom, Annika.,Nookaew, Intawat.,...&Backhed, Fredrik.(2019).Simplified intestinal microbiota to study microbe-diet-host interactions in a mouse model.Cell reports,26(13),3772-+. |
| MLA | Kovatcheva-Datchary, Petia,et al."Simplified intestinal microbiota to study microbe-diet-host interactions in a mouse model".Cell reports 26.13(2019):3772-+. |
| 个性服务 |
| 查看访问统计 |
| 相关权益政策 |
| 暂无数据 |
| 收藏/分享 |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论