BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes

doi:10.1016/j.ijbiomac.2017.08.042

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	BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes
	Xu, Qi 1,2,3; Luo, Jiao 1,2,3; Wu, Ning 1,3; Zhang, Renshuai 1,3; Shi, Dayong 1,2,3
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2018
卷号	106 页码:379-386
关键词	Bpn Protein Tyrosine Phosphatase 1b Insulin Signaling Insulin Resistance C2c12 Myotubes
DOI	10.1016/j.ijbiomac.2017.08.042
文献子类	Article
英文摘要	Insulin resistance is a key feature of type 2 diabetes mellitus (T2DM) and is characterized by defects in insulin signaling. Protein tyrosine phosphatase 1B (PTP1B) is a major negative regulator of insulin signaling cascade and has attracted intensive investigation in recent T2DM therapy study. BPN, a marine derived bromophenol compound, was isolated from the red alga Rhodomela confervoides. This study investigated the effects of BPN on the insulin signaling pathway in insulin-resistant C2C12 myotubes by inhibiting PTP1B. Molecular docking study and analysis of small-molecule interaction with PTP1B all showed BPN inhibited PTP1B activity via binding to the catalytic site through hydrogen bonds. We then found that BPN permeated into C2C12 myotubes, on the one hand, activated insulin signaling in an insulin independent manner in C2C12 cells; on the other hand, ameliorated palmitate-induced insulin resistance through augmenting insulin sensitivity. Moreover, our studies also showed that FTP1B inhibition by BPN increased glucose uptake in normal and insulin-resistant C2C12 myotubes through glucose transporter 4 (GLUT4) translocation. Taken together, BPN activates insulin signaling and alleviates insulin resistance and represents a potential candidate for further development as an antidiabetic agent. (C) 2017 Elsevier B.V. All rights reserved.
语种	英语
WOS记录号	WOS:000417661600043
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/154321]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Xu, Qi,Luo, Jiao,Wu, Ning,et al. BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,106:379-386.
APA	Xu, Qi,Luo, Jiao,Wu, Ning,Zhang, Renshuai,&Shi, Dayong.(2018).BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,106,379-386.
MLA	Xu, Qi,et al."BPN, a marine-derived PTP1B inhibitor, activates insulin signaling and improves insulin resistance in C2C12 myotubes".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 106(2018):379-386.