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	Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132
	Liu, Dong2,3; Li, Xiao-Ming2; Meng, Li1; Li, Chun-Shun2; Gao, Shu-Shan2,3; Shang, Zhuo2,3; Proksch, Peter4; Huang, Cai-Guo1; Wang, Bin-Gui2
刊名	JOURNAL OF NATURAL PRODUCTS
	2011-08-01
卷号	74期号:8页码:1787-1791
ISSN号	0163-3864
DOI	10.1021/np200381u
文献子类	Article
英文摘要	Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.; Eight new a-pyrone derivatives, namely, nigerapyrones A-E (1-5) and nigerapyrones F-H (8-10), along with two known congeners, asnipyrones B (6) and A (7), were isolated from Aspergillus niger MA-132, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The undescribed geometries of the trisubstituted double bonds (C-9 and C-11) for asnipyrone B (6) have now been explicitly determined, while the incorrect placement of the methyl group at C-5 of asnipyrone A (7) has now been revised at C-3. The cytotoxic activities of the isolated a-pyrone derivatives against eight tumor cell lines as well as antimicrobial activities against two bacteria and four plant-pathogenic fungi of these compounds were evaluated. Compounds 2, 4, 5, and 7 showed weak cytotoxicity against some of the tested tumor cell lines.
学科主题	Plant Sciences ; Pharmacology & Pharmacy
URL标识	查看原文
语种	英语
WOS记录号	WOS:000294242800016
公开日期	2012-07-03
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/11908]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 4.Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany
推荐引用方式 GB/T 7714	Liu, Dong,Li, Xiao-Ming,Meng, Li,et al. Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132[J]. JOURNAL OF NATURAL PRODUCTS,2011,74(8):1787-1791.
APA	Liu, Dong.,Li, Xiao-Ming.,Meng, Li.,Li, Chun-Shun.,Gao, Shu-Shan.,...&Wang, Bin-Gui.(2011).Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132.JOURNAL OF NATURAL PRODUCTS,74(8),1787-1791.
MLA	Liu, Dong,et al."Nigerapyrones A-H, alpha-Pyrone Derivatives from the Marine Mangrove-Derived Endophytic Fungus Aspergillus niger MA-132".JOURNAL OF NATURAL PRODUCTS 74.8(2011):1787-1791.

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