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	Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum
	Li, Dong-Li1,2; Li, Xiao-Ming1; Li, Tie-Gang3; Dang, Hong-Yue3; Wang, Bin-Gui1
刊名	HELVETICA CHIMICA ACTA
	2008
卷号	91期号:10页码:1888-1893
关键词	Aspergillus-amstelodami Diketopiperazine Isoechinulin
ISSN号	0018-019X
文献子类	Article
英文摘要	Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus, resulted in the isolation of two new dioxopiperazine derivatives, namely, dehydrovariecolorin L (1) and dehydroechinulin (2), together with eight known dioxopiperazine compounds including variecolorin L (3), echinulin (4), isoechinulin A (5), dihydroxyisoechinulin A (6), preechinulin (7), neoechinulin A (8), neoechinulin E (9), and cryptoechinuline D (10). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. Compounds 1, 2, 9, and 10 were investigated for their a,a-diphenyl-beta-picrylhydrazyl (DPPH) radical-scavenging activity. In addition, the new compounds, 1 and 2, were evaluated for their cytotoxic activity against the P-388, HL-60, and A549 cell lines.; Cultivation of the fungal strain Eurotium rubrum, an endophytic fungus that was isolated from the inner tissue of stems of the mangrove plant Hibiscus tiliaceus, resulted in the isolation of two new dioxopiperazine derivatives, namely, dehydrovariecolorin L (1) and dehydroechinulin (2), together with eight known dioxopiperazine compounds including variecolorin L (3), echinulin (4), isoechinulin A (5), dihydroxyisoechinulin A (6), preechinulin (7), neoechinulin A (8), neoechinulin E (9), and cryptoechinuline D (10). The structures of the isolated compounds were determined by extensive analysis of their spectroscopic data as well as by comparison with literature. Compounds 1, 2, 9, and 10 were investigated for their a,a-diphenyl-beta-picrylhydrazyl (DPPH) radical-scavenging activity. In addition, the new compounds, 1 and 2, were evaluated for their cytotoxic activity against the P-388, HL-60, and A549 cell lines.
语种	英语
WOS记录号	WOS:000261050300009
公开日期	2010-12-30
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/6289]
专题	海洋研究所_实验海洋生物学重点实验室 海洋研究所_海洋地质与环境重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Geol & Environm, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Li, Dong-Li,Li, Xiao-Ming,Li, Tie-Gang,et al. Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum[J]. HELVETICA CHIMICA ACTA,2008,91(10):1888-1893.
APA	Li, Dong-Li,Li, Xiao-Ming,Li, Tie-Gang,Dang, Hong-Yue,&Wang, Bin-Gui.(2008).Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum.HELVETICA CHIMICA ACTA,91(10),1888-1893.
MLA	Li, Dong-Li,et al."Dioxopiperazine Alkaloids Produced by the Marine Mangrove Derived Endophytic Fungus Eurotium rubrum".HELVETICA CHIMICA ACTA 91.10(2008):1888-1893.

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