Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor

doi:10.1016/j.cclet.2008.07.002

	Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor
	Li, Jing1,2 ; Guo, Shu Ju 1,2; Su, Hua 1,2; Han, Li Jun 1; shi, Da Yong 1
刊名	CHINESE CHEMICAL LETTERS
	2008-11-01
卷号	19 期号:11 页码:1290-1292
关键词	Bromophenol Ptp1b Inhibitor Bis-(2 Total Synthesis 3-dibromo-4 5-dihydroxyphenyl)-methane
ISSN号	1001-8417
DOI	10.1016/j.cclet.2008.07.002
文献子类	Article
英文摘要	Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator and has been proved to be an effective target for the treatment of type 2 diabetes mellitus. Bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane 7 was first reported as a natural bromophenol with significant inhibition against PTP1B which was isolated from red algae Rhodomela confervoides. Intrigued by its astonishing activity (IC(50) = 2.4 mu mol/L), compound 7 was synthesized with the overall yield of 24% and evaluated for its PTP1B inhibitory activity compared with natural compound. (C) 2008 Li Jun Han. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.; Protein tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator and has been proved to be an effective target for the treatment of type 2 diabetes mellitus. Bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane 7 was first reported as a natural bromophenol with significant inhibition against PTP1B which was isolated from red algae Rhodomela confervoides. Intrigued by its astonishing activity (IC50 = 2.4 mu mol/L), compound 7 was synthesized with the overall yield of 24% and evaluated for its PTP1B inhibitory activity compared with natural compound. (C) 2008 Li Jun Han. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
学科主题	Chemistry, Multidisciplinary
URL标识	查看原文
语种	英语
WOS记录号	WOS:000263323500008
公开日期	2010-12-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/6063]
专题	海洋研究所_海洋生物技术研发中心海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Jing,Guo, Shu Ju,Su, Hua,et al. Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor[J]. CHINESE CHEMICAL LETTERS,2008,19(11):1290-1292.
APA	Li, Jing,Guo, Shu Ju,Su, Hua,Han, Li Jun,&shi, Da Yong.(2008).Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor.CHINESE CHEMICAL LETTERS,19(11),1290-1292.
MLA	Li, Jing,et al."Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor".CHINESE CHEMICAL LETTERS 19.11(2008):1290-1292.