Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships

doi:10.1007/s00239-005-0026-2

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	Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships
	Zhao, Fangqing ; Qin, Song
刊名	JOURNAL OF MOLECULAR EVOLUTION
	2006-09-01
卷号	63 期号:3 页码:330-340
关键词	Covariation Analysis Cyanobacteria Phycobiliprotein Positive Selection
ISSN号	0022-2844
DOI	10.1007/s00239-005-0026-2
文献子类	Article
英文摘要	Phycobiliproteins, together with linker polypeptides and various chromophores, are basic building blocks of phycobilisomes, a supramolecular complex with a light-harvesting function in cyanobacteria and red algae. Previous studies suggest that the different types of phycobiliproteins and the linker polypeptides originated from the same ancestor. Here we retrieve the phycobilisome-related genes from the well-annotated and even unfinished cyanobacteria genomes and find that many sites with elevated d(N)/d(S) ratios in different phycobiliprotein lineages are located in the chromophore-binding domain and the helical hairpin domains (X and Y). Covariation analyses also reveal that these sites are significantly correlated, showing strong evidence of the functional-structural importance of interactions among these residues. The potential selective pressure driving the diversification of phycobiliproteins may be related to the phycobiliprotein-chromophore microenvironment formation and the subunits interaction. Sites and genes identified here would provide targets for further research on the structural-functional role of these residues and energy transfer through the chromophores.; Phycobiliproteins, together with linker polypeptides and various chromophores, are basic building blocks of phycobilisomes, a supramolecular complex with a light-harvesting function in cyanobacteria and red algae. Previous studies suggest that the different types of phycobiliproteins and the linker polypeptides originated from the same ancestor. Here we retrieve the phycobilisome-related genes from the well-annotated and even unfinished cyanobacteria genomes and find that many sites with elevated d(N)/d(S) ratios in different phycobiliprotein lineages are located in the chromophore-binding domain and the helical hairpin domains (X and Y). Covariation analyses also reveal that these sites are significantly correlated, showing strong evidence of the functional-structural importance of interactions among these residues. The potential selective pressure driving the diversification of phycobiliproteins may be related to the phycobiliprotein-chromophore microenvironment formation and the subunits interaction. Sites and genes identified here would provide targets for further research on the structural-functional role of these residues and energy transfer through the chromophores.
学科主题	Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
URL标识	查看原文
语种	英语
WOS记录号	WOS:000240797800003
公开日期	2010-12-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/5987]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Qingdao, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Fangqing,Qin, Song. Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships[J]. JOURNAL OF MOLECULAR EVOLUTION,2006,63(3):330-340.
APA	Zhao, Fangqing,&Qin, Song.(2006).Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships.JOURNAL OF MOLECULAR EVOLUTION,63(3),330-340.
MLA	Zhao, Fangqing,et al."Evolutionary analysis of phycobiliproteins: Implications for their structural and functional relationships".JOURNAL OF MOLECULAR EVOLUTION 63.3(2006):330-340.