Cytotoxic ergosteroids from the fungus Stereum hirsutum

doi:10.1016/j.phytol.2019.02.007

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Cytotoxic ergosteroids from the fungus Stereum hirsutum
	Zhao, Zhen-Zhu 1,2,3; Han, Kai-Yue 4; Li, Zheng-Hui 4; Feng, Tao 4; Chen, He-Ping 4,5; Liu, Ji-Kai 4,5
刊名	PHYTOCHEMISTRY LETTERS
	2019-04-01
卷号	30 页码:143-149
关键词	Stereum hirsutum Steroids Semi-synthesis Cytotoxicity
ISSN号	1874-3900
DOI	10.1016/j.phytol.2019.02.007
通讯作者	Chen, He-Ping(chenhp@mail.scuec.edu.cn) ; Liu, Ji-Kai(jkliu@mail.kib.ac.cn)
英文摘要	Phytochemical investigation on the fermentation broth of the fungus Stereum hirsutum led to the isolation of ten steroids, including two previously unreported ones, namely steresterones A (1) and B (2). The semi-synthesis products 3a and 3b were prepared by reduction of the known compound 3 with NaBH4. Their structures and absolute configurations were established via 1D & 2D NMR spectroscopic analysis, and TDDFT/ECD calculations as well as single crystal X-ray diffraction analysis. The structure of 3 which harbored a 5 beta-H was confirmed by single crystal X-ray diffraction analysis for the first time. All the compounds reported in this study were evaluated for their cytotoxicity against five human cancer cell lines. Bioassay results revealed that 3, 4, 6-9 displayed significant anti-proliferative effects with IC50 values varying from 2.3 to 34.3 mu M. The structure-activity relationships of 3, 3a, 3b were discussed.
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000461363900028
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64996]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Chen, He-Ping; Liu, Ji-Kai
作者单位	1.Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengshou 450046, Peoples R China 2.Henan Univ Chinese Med, Chinese Med Dev Henan Prov, Zhengshou 450046, Peoples R China 3.Henan Univ Chinese Med, Sch Pharm, Zhengsshou 450046, Peoples R China 4.South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China 5.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,et al. Cytotoxic ergosteroids from the fungus Stereum hirsutum[J]. PHYTOCHEMISTRY LETTERS,2019,30:143-149.
APA	Zhao, Zhen-Zhu,Han, Kai-Yue,Li, Zheng-Hui,Feng, Tao,Chen, He-Ping,&Liu, Ji-Kai.(2019).Cytotoxic ergosteroids from the fungus Stereum hirsutum.PHYTOCHEMISTRY LETTERS,30,143-149.
MLA	Zhao, Zhen-Zhu,et al."Cytotoxic ergosteroids from the fungus Stereum hirsutum".PHYTOCHEMISTRY LETTERS 30(2019):143-149.