C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba

doi:10.1021/acs.jafc.8b02066

	C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba
	Meng, Xiu-Hua; Zhu, Hong-Tao; Yan, Hui; Wang, Dong; Yang, Chong-Ren; Zhang, Ying-Jun
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2018
卷号	66 期号:27 页码:7150-7155
关键词	Camellia sinensis var. pubilimba green tea C-8 N-ethyl-2-pyrrolidinone substituted flavan-3-ols AChE inhibitory activity antioxidant
ISSN号	0021-8561
DOI	10.1021/acs.jafc.8b02066
通讯作者	Zhang, Ying-Jun(zhangyj@mail.kib.ac.cn)
英文摘要	Camellia sinensis var. pubilimba, one variety of the genus Camellia sect. Thea (Theaceae), has been used for producing green tea mainly by the local people of its growing areas of Guangxi province, China. Forty compounds, including eight C-8 N-ethyl-2-pyrrolidinone-substituted flavan-3-ols (1-8) and their substituted unit N-ethyl-5-hydroxy-2-pyrrolidinone (9), four flavan-3-ol monomers (10-13) and one dimer (14), nine flavonoids (15-23), three hydrolyzable tannins (24-26), two lignans (27-28), 11 simple phenolics (29-39), and caffeine (40), were first isolated and identified from the leaves. Their structures were determined by detailed spectroscopic analysis and comparison with the literature data and authentic samples. Both 1 and 4 were obtained as a mixture of the N-ethyl-2-pyrrolidinone C-5 enantiomers (la and lb and 4a and 4b), respectively, while the resolution of another three pairs of enantiomers (2 and 3, 5 and 6, and 7 and 8) was achieved. Among them, lb is a new compound whose NMR data together with its enantiomer (la) were reported for the first time, while 2 and 3 are two new natural products. Most of the isolates exhibited significant antioxidant activities, stronger than ascorbic acid and trolox, while parts of the isolates, particularly C-8 N-ethyl-2-pyrrolidinone-substituted flavan-3-ols, showed obvious inhibitory effects on acetylcholinesterase (AChE). The results indicated that C. sinensis var. pubilimba is a valuable plant resource for tea production.
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
WOS记录号	WOS:000439008800021
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/64710]
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Meng, Xiu-Hua,Zhu, Hong-Tao,Yan, Hui,et al. C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(27):7150-7155.
APA	Meng, Xiu-Hua,Zhu, Hong-Tao,Yan, Hui,Wang, Dong,Yang, Chong-Ren,&Zhang, Ying-Jun.(2018).C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(27),7150-7155.
MLA	Meng, Xiu-Hua,et al."C-8 N-Ethyl-2-pyrrolidinone-Substituted Flavan-3-ols from the Leaves of Camellia sinensis var. pubilimba".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.27(2018):7150-7155.