| Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds | |
Zhang, Jun5; Shao, Chang-Lun4; Qian, Pei-Yuan2,3; Wang, Kai-Ling3,4; Xu, Ying3,6; Lu, Liang2; Li, Yongxin3; Han, Zhuang1,3 ; Wang, Chang-Yun4
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| 刊名 | MARINE BIOTECHNOLOGY
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| 2015-10-01 | |
| 卷号 | 17期号:5页码:624-632 |
| 关键词 | Biofouling Low-toxicity Antifouling Compounds Diindol-3-ylmethane Pseudovibrio |
| DOI | 10.1007/s10126-015-9656-6 |
| 文献子类 | Article |
| 英文摘要 | In the present study, eight natural products that belonged to di(1H-indol-3-yl)methane (DIM) family were isolated from Pseudovibrio denitrificans UST4-50 and tested for their antifouling activity against larval settlement (including both attachment and metamorphosis) of the barnacle Balanus (=Amphibalanus) amphitrite and the bryozoan Bugula neritina. All diindol-3-ylmethanes (DIMs) showed moderate to strong inhibitory effects against larval settlement of B. amphitrite with EC50 values ranging from 18.57 to 1.86 mu M and could be considered as low-toxicity antifouling compounds since their LC50/EC50 ratios were larger than 15. Furthermore, the DIM- and 4-(di(1H-indol-3-yl)methyl)phenol (DIM-Ph-4-OH)-treated larvae completed normal settlement when they were transferred to clean seawater after being exposed to those compounds for 24 h. DIM also showed comparable antifouling performance to the commercial antifouling biocide Sea-Nine 211 (TM) in the field test over a period of 5 months, which further confirmed that DIMs can be considered as promising candidates of environmentally friendly antifouling compounds. |
| URL标识 | 查看原文 |
| WOS关键词 | VIBRIO-PARAHAEMOLYTICUS ; INDOLE ALKALOIDS ; MARINE SPONGES ; BACTERIUM ; METABOLITES ; INHIBITION ; ATTACHMENT ; BARNACLE ; BRYOZOAN ; BIOFILMS |
| 语种 | 英语 |
| WOS记录号 | WOS:000359948100008 |
| 内容类型 | 期刊论文 |
| 版本 | 出版稿 |
| 源URL | [http://124.16.218.2:8080/handle/183446/784]  |
| 专题 | 深海科学研究部_深海生物学研究室_深海微生物活性物质研究组 |
| 作者单位 | 1.Chinese Acad Sci, Sanya Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China 2.Hong Kong Univ Sci & Technol, Environm Sci Program, Sch Sci, Clear Water Bay, Hong Kong, Peoples R China 3.Hong Kong Univ Sci & Technol, Div Life Sci, Clear Water Bay, Hong Kong, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China 5.Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong, Peoples R China 6.Shenzhen Univ, Coll Life Sci, Shenzhen 518060, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jun,Shao, Chang-Lun,Qian, Pei-Yuan,et al. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds[J]. MARINE BIOTECHNOLOGY,2015,17(5):624-632. |
| APA | Zhang, Jun.,Shao, Chang-Lun.,Qian, Pei-Yuan.,Wang, Kai-Ling.,Xu, Ying.,...&Wang, Chang-Yun.(2015).Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds.MARINE BIOTECHNOLOGY,17(5),624-632. |
| MLA | Zhang, Jun,et al."Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds".MARINE BIOTECHNOLOGY 17.5(2015):624-632. |
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