The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination | |
Yu, Fang1,5; Sharma, Suveena1; Gurram, Rama Krishna1; Rieder, Sadiye1; Zhu, Jinfang1; Jankovic, Dragana2; Su, Pan3; Sun, Bing3; Hu, Gangqing4; Li, Rao4 | |
刊名 | JOURNAL OF EXPERIMENTAL MEDICINE |
2018 | |
卷号 | 215期号:7页码:1813-1821 |
关键词 | Regulatory T-cells Toxoplasma-gondii Ifn-gamma Scid Mice Bet Interleukin-10 Differentiation Expression Responses Prevents |
ISSN号 | 0022-1007 |
DOI | 10.1084/jem.20170155 |
文献子类 | Article |
英文摘要 | Type 1 T helper (Th1) cells play a critical role in host defense against intracellular pathogens and in autoimmune diseases by producing a key inflammatory cytokine interferon (IFN)-gamma; some Th1 cells can also be antiinflammatory through producing IL-10. However, the molecular switch for regulating the differentiation of inflammatory and antiinflammatory Th1 cells is still elusive. Here, we show that Bhlhe40-deficient CD4 Th1 cells produced less IFN-gamma but substantially more IL-10 than wildtype Th1 cells both in vitro and in vivo. Bhlhe40-mediated IFN-gamma production was independent of transcription factor T-bet regulation. Mice with conditional deletion of Bhlhe40 in T cells succumbed to Toxoplasma gondii infection, and blockade of IL-10 signaling during infection rescued these mice from death. Thus, our results demonstrate that transcription factor Bhlhe40 is a molecular switch for determining the fate of inflammatory and antiinflammatory Th1 cells. |
电子版国际标准刊号 | 1540-9538 |
WOS研究方向 | Immunology ; Medicine, Research & Experimental |
语种 | 英语 |
WOS记录号 | WOS:000440822900007 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3504] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Yu, Fang; Sun, Bing |
作者单位 | 1.NIAID, Immunol Lab, NIH, Bldg 10, Bethesda, MD 20892 USA; 2.NIAID, Parasit Dis Lab, NIH, Bethesda, MD USA; 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, CAS Ctr Excellence Mol Cell Sci,State Key Lab Cel, Shanghai, Peoples R China; 4.NHLBI, Lab Epigenome Biol, Syst Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA; 5.Weill Cornell Med Coll, Dept Physiol & Biophys, Doha, Qatar |
推荐引用方式 GB/T 7714 | Yu, Fang,Sharma, Suveena,Gurram, Rama Krishna,et al. The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination[J]. JOURNAL OF EXPERIMENTAL MEDICINE,2018,215(7):1813-1821. |
APA | Yu, Fang.,Sharma, Suveena.,Gurram, Rama Krishna.,Rieder, Sadiye.,Zhu, Jinfang.,...&Zhao, Keji.(2018).The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination.JOURNAL OF EXPERIMENTAL MEDICINE,215(7),1813-1821. |
MLA | Yu, Fang,et al."The transcription factor Bhlhe40 is a switch of inflammatory versus antiinflammatory Th1 cell fate determination".JOURNAL OF EXPERIMENTAL MEDICINE 215.7(2018):1813-1821. |
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