Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty | |
Peng, Yi Jacky1,2; Yu, Hua1,2; Dong, Wenjie1,2; Yin, Xiujuan1,2; Lin, Minghui1,2; Zhou, Bo O.1,2; Hao, Xiaoxin3; Zheng, Junke3 | |
刊名 | EMBO JOURNAL |
2018 | |
卷号 | 37期号:17页码:e98984 |
关键词 | Estrogen-receptor-alpha Knockout Lurko Mice Bone-marrow Essential Thrombocythemia Lymphoid Progenitors b Lymphopoiesis Self-renewal Risk-factor Identification Maintenance |
ISSN号 | 0261-4189 |
DOI | 10.15252/embj.201898984 |
文献子类 | Article |
英文摘要 | The number and self-renewal capacity of hematopoietic stem cells (HSCs) are tightly regulated at different developmental stages. Many pathways have been implicated in regulating HSC development in cell autonomous manners; however, it remains unclear how HSCs sense and integrate developmental cues. In this study, we identified an extrinsic mechanism by which HSC number and functions are regulated during mouse puberty. We found that the HSC number in postnatal bone marrow reached homeostasis at 4 weeks after birth. Luteinizing hormone, but not downstream sex hormones, was involved in regulating HSC homeostasis during this period. Expression of luteinizing hormone receptor (Lhcgr) is highly restricted in HSCs and multipotent progenitor cells in the hematopoietic hierarchy. When Lhcgr was deleted, HSCs continued to expand even after 4 weeks after birth, leading to abnormally elevated hematopoiesis and leukocytosis. In a murine acute myeloid leukemia model, leukemia development was significantly accelerated upon Lhcgr deletion. Together, our work reveals an extrinsic counting mechanism that restricts HSC expansion during development and is physiologically important for maintaining normal hematopoiesis and inhibiting leukemogenesis. |
电子版国际标准刊号 | 1460-2075 |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
语种 | 英语 |
WOS记录号 | WOS:000443413000007 |
内容类型 | 期刊论文 |
版本 | 出版稿 |
源URL | [http://202.127.25.143/handle/331003/3434] |
专题 | 生化所2018年发文 上海生化细胞研究所_上海生科院生化细胞研究所 |
通讯作者 | Zhou, Bo O. |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, State Key Lab Cell Biol, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Shanghai, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Chinese Minist Educ,Dept Pathophysiol, Shanghai, Peoples R China |
推荐引用方式 GB/T 7714 | Peng, Yi Jacky,Yu, Hua,Dong, Wenjie,et al. Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty[J]. EMBO JOURNAL,2018,37(17):e98984. |
APA | Peng, Yi Jacky.,Yu, Hua.,Dong, Wenjie.,Yin, Xiujuan.,Lin, Minghui.,...&Zheng, Junke.(2018).Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty.EMBO JOURNAL,37(17),e98984. |
MLA | Peng, Yi Jacky,et al."Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty".EMBO JOURNAL 37.17(2018):e98984. |
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