Recent advances of self-assembling peptide-based hydrogels for biomedical applications

doi:10.1039/c8sm02573h

	Recent advances of self-assembling peptide-based hydrogels for biomedical applications
	Li, Jieling; Xing, Ruirui; Bai, Shuo; Yan, Xuehai
刊名	SOFT MATTER
	2019-02-28
卷号	15 期号:8 页码:1704-1715
ISSN号	1744-683X
DOI	10.1039/c8sm02573h
英文摘要	Peptide-based hydrogels have been proven to be preeminent biomedical materials due to their high water content, tunable mechanical stability, great biocompatibility and excellent injectability. The ability of peptide-based hydrogels to provide extracellular matrix-mimicking environments opens up opportunities for their biomedical applications in fields such as drug delivery, tissue engineering, and wound healing. In this review, we first describe several methods commonly used for the fabrication of robust peptide-based hydrogels, including spontaneous hydrogelation, enzyme-controlled hydrogelation and cross-linking-enhanced hydrogelation. We then introduce some representative studies on their applications in drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering. We hope that this review facilitates the advances of hydrogels in biomedical applications.
资助项目	National Natural Science Foundation of China[21774132] ; National Natural Science Foundation of China[21703253] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802144] ; National Natural Science Foundation of China[21802143] ; National Natural Sciences Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS关键词	DIPEPTIDE-BASED NANOCARRIERS ; CROSS-LINKING ; SUPRAMOLECULAR HYDROGELS ; ENZYMATIC HYDROGELATION ; MECHANICAL-PROPERTIES ; HYBRID HYDROGEL ; DELIVERY-SYSTEM ; DRUG-DELIVERY ; BETA-SHEET ; ANTITUMOR
WOS研究方向	Chemistry ; Materials Science ; Physics ; Polymer Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000459482400001
资助机构	National Natural Science Foundation of China ; National Natural Sciences Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/27973]
专题	中国科学院过程工程研究所
通讯作者	Bai, Shuo; Yan, Xuehai
作者单位	Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Li, Jieling,Xing, Ruirui,Bai, Shuo,et al. Recent advances of self-assembling peptide-based hydrogels for biomedical applications[J]. SOFT MATTER,2019,15(8):1704-1715.
APA	Li, Jieling,Xing, Ruirui,Bai, Shuo,&Yan, Xuehai.(2019).Recent advances of self-assembling peptide-based hydrogels for biomedical applications.SOFT MATTER,15(8),1704-1715.
MLA	Li, Jieling,et al."Recent advances of self-assembling peptide-based hydrogels for biomedical applications".SOFT MATTER 15.8(2019):1704-1715.