Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors.

	Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors.
	Yu, Yang; Hu, Cheng; Xia, Lin; Wang, Jiangyun
刊名	ACS CATALYSIS
	2018
文献子类	期刊论文
英文摘要	There are 20 proteinogenic amino acids and a limited number of cofactors naturally available to build enzymes. Genetic codon expansion enables us to incorporate more than 200 unnatural amino acids into proteins using cell translation machinery, greatly expanding structures available to protein chemists. Such tools enable scientists to mimic the active site of an enzyme to tune enzymatic activity, anchor cofactors, and immobilize enzymes on electrode surfaces. Non-native cofactors can be incorporated into the protein through covalent or noncovalent interactions, expanding the reaction scope of existing enzymes. The review discusses strategies to incorporate unnatural amino acids and non-native cofactors and their applications in tuning and expanding enzymatic activities of artificial metalloenzymes.
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13420]
专题	合成所
推荐引用方式 GB/T 7714	Yu, Yang,Hu, Cheng,Xia, Lin,et al. Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors.[J]. ACS CATALYSIS,2018.
APA	Yu, Yang,Hu, Cheng,Xia, Lin,&Wang, Jiangyun.(2018).Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors..ACS CATALYSIS.
MLA	Yu, Yang,et al."Artificial Metalloenzyme Design with Unnatural Amino Acids and Non-Native Cofactors.".ACS CATALYSIS (2018).