Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone.

	Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone.
	Yang Fan; Huang Shishu; Li Zhenxia; Liu Yunhui; Gao Dashuang; Zhang Xinzhou; Hao Jin
刊名	JOURNAL OF CELLULAR PHYSIOLOGY
	2018
文献子类	期刊论文
英文摘要	The metabolism and homeostasis of skeletal system has historically been regarded to be associated with the endocrine system. However, such view has been expanded with the recognition of several neural pathways playing important roles in the regulation of bone metabolism via central relays. In particular, bone metabolism and homeostasis has been reported to be precisely modulated by the central neural signaling. Initiated by the finding of leptin, the axis of neural regulation on bone expands rapidly. Semaphorin-plexin system play an important role in the crosstalk between osteoclasts and osteoblasts, a complex system has also been identified and includes neuropeptide Y and cannabinoids. These findings facilitate our understanding of the central neuropeptides and neural factors in the modulation of bone metabolism and homeostasis, and these neuronal pathways also represent an area of research scenario that identifies the novel regulation between brain and bone. These regulatory mechanisms correlate with other homeostatic networks and demonstrate a more intricate and synergetic bone biology than previously envisioned. As such, this review summarizes the current knowledge of the neural regulation of bone metabolism and homeostasis as well as its role in skeletal diseases, and discusses the emerging challenges presented in this field. This article is protected by copyright. All rights reserved.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13884]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Yang Fan,Huang Shishu,Li Zhenxia,et al. Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone.[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2018.
APA	Yang Fan.,Huang Shishu.,Li Zhenxia.,Liu Yunhui.,Gao Dashuang.,...&Hao Jin.(2018).Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone..JOURNAL OF CELLULAR PHYSIOLOGY.
MLA	Yang Fan,et al."Neural Regulation of Bone Remodeling: Identifying Novel Neural Molecules and Pathways Between Brain and Bone.".JOURNAL OF CELLULAR PHYSIOLOGY (2018).