Differential effects of Foxp2 disruption in distinct motor circuits.

	Differential effects of Foxp2 disruption in distinct motor circuits.
	Chris I. De Zeeuw; Catherine A. French; Kuikui Zhou; María F. Vinueza Veloz; Saša Peter; Simon E. Fisher; Rui M. Costa
刊名	Molecular Psychiatry
	2018
文献子类	期刊论文
英文摘要	Disruptions of the FOXP2 gene cause a speech and language disorder involving difficulties in sequencing orofacial movements. FOXP2 is expressed in cortico-striatal and cortico-cerebellar circuits important for fine motor skills, and affected individuals show abnormalities in these brain regions. We selectively disrupted Foxp2 in the cerebellar Purkinje cells, striatum or cortex of mice and assessed the effects on skilled motor behaviour using an operant lever-pressing task. Foxp2 loss in each region impacted behaviour differently, with striatal and Purkinje cell disruptions affecting the variability and the speed of lever-press sequences, respectively. Mice lacking Foxp2 in Purkinje cells showed a prominent phenotype involving slowed lever pressing as well as deficits in skilled locomotion. In vivo recordings from Purkinje cells uncovered an increased simple spike firing rate and decreased modulation of firing during limb movements. This was caused by increased intrinsic excitability rather than changes in excitatory or inhibitory inputs. Our findings show that Foxp2 can modulate different aspects of motor behaviour in distinct brain regions, and uncover an unknown role for Foxp2 in the modulation of Purkinje cell activity that severely impacts skilled movements.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/13874]
专题	深圳先进技术研究院_脑所
推荐引用方式 GB/T 7714	Chris I. De Zeeuw,Catherine A. French,Kuikui Zhou,et al. Differential effects of Foxp2 disruption in distinct motor circuits.[J]. Molecular Psychiatry,2018.
APA	Chris I. De Zeeuw.,Catherine A. French.,Kuikui Zhou.,María F. Vinueza Veloz.,Saša Peter.,...&Rui M. Costa.(2018).Differential effects of Foxp2 disruption in distinct motor circuits..Molecular Psychiatry.
MLA	Chris I. De Zeeuw,et al."Differential effects of Foxp2 disruption in distinct motor circuits.".Molecular Psychiatry (2018).