odonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combinedwith Streptozotocin

	odonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combinedwith Streptozotocin
	Qing-Yun Li; Ya-Qian Dong; Feng-Hua Zhou; Xian-Yuan Lu; Meng-Hua Liu; Jing-Yu He; Zheng Cai; Lan Tang; Lin-Na Gong
刊名	Natural Products and Bioprospecting
	2018
文献子类	期刊论文
英文摘要	Diabetic kidney disease (DKD) is the most serious microvascular complication during the development of diabetes with the characterizations of glomerular basement membrane thickening, mesangial expansion, and glomerular sclerosis, eventually leading to end-stage renal disease. This study aimed to investigate the melioration effect of Codonopisis tangshen Oliv. (COD) on the DKD model, which was established by unilateral nephrectomy (UN)-high fat diet feeding (HFD) combined with streptozotocin (STZ). After the DKD rats were oral treated with COD at a dose of 2.7 mg/kg for 4 consecutive weeks, the blood glucose, lipid metabolism, renal function, inflammatory mediators, and fibrosis-associated proteins were examined. In vivo, the COD administration obviously relieved the weight loss, water intake, and blood glucose; decreased the total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels; and improved the renal function by reducing the expression of serum creatinine, uric acid, and urinary protein compared with the model group. The levels of pro-inflammatory cytokines of tumor necrosis factor-α, interleukin-1β, and IL-6 were significantly inhibited by COD. Meanwhile, the deposition of collagen fiber was markedly increased, and the protein and mRNA expressions of transforming growth factor-β1 and α-smooth muscle actin were markedly elevated in DKD rats, but they were decreased to some extent after the COD treatment. In conclusion, COD exhibited a protective effect on the UN-HFD feeding combined with STZ-induced DKD model by improving the blood glucose and lipid metabolism, relieving the inflammatory response, and mitigating the renal fibrosis, which provided scientific evidence for its applications in clinic.
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14780]
专题	深圳先进技术研究院_南沙所
推荐引用方式 GB/T 7714	Qing-Yun Li,Ya-Qian Dong,Feng-Hua Zhou,et al. odonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combinedwith Streptozotocin[J]. Natural Products and Bioprospecting,2018.
APA	Qing-Yun Li.,Ya-Qian Dong.,Feng-Hua Zhou.,Xian-Yuan Lu.,Meng-Hua Liu.,...&Lin-Na Gong.(2018).odonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combinedwith Streptozotocin.Natural Products and Bioprospecting.
MLA	Qing-Yun Li,et al."odonopsis tangshen Oliv. Amelioration Effect on Diabetic Kidney Disease Rats Induced by High Fat Diet Feeding Combinedwith Streptozotocin".Natural Products and Bioprospecting (2018).