Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light

	Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light
	Li, Jun; Liu, Xiangmei; Cui, Zhenduo; Yang, Xianjin; Zhu, Shengli; Li, Zhaoyang; Yuan, Xubo; Zheng, Yufeng; Yeung, Kelvin W. K.; Pan, Haobo
刊名	ADVANCED MATERIALS
	2018
文献子类	期刊论文
英文摘要	Bone-implant-associated infections are common after orthopedic surgery due to impaired host immune response around the implants. In particular, when a biofilm develops, the immune system and antibiotic treatment find it difficult to eradicate, which sometimes requires a second operation to replace the infected implants. Most strategies have been designed to prevent biofilms from forming on the surface of bone implants, but these strategies cannot eliminate the biofilm when it has been established in vivo. To address this issue, a nonsurgical, noninvasive treatment for biofilm infection must be developed. Herein, a red-phosphorus-IR780-arginine-glycine-aspartic-acid-cysteine coating on titanium bone implants is prepared. The red phosphorus has great biocompatibility and exhibits efficient photothermal ability. The temperature sensitivity of Staphylococcus aureus biofilm is enhanced in the presence of singlet oxygen (O-1(2)) produced by IR780. Without damaging the normal tissue, the biofilm can be eradicated through a safe near-infrared (808 nm) photothermal therapy at 50 degrees C in vitro and in vivo. This approach reaches an antibacterial efficiency of 96.2% in vivo with 10 min of irradiation at 50 degrees C. Meanwhile, arginine-glycine-aspartic-acidcysteine decorated on the surface of the implant can improve the cell adhesion, proliferation, and osteogenic differentiation.
URL标识	查看原文
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/14729]
专题	深圳先进技术研究院_医药所
推荐引用方式 GB/T 7714	Li, Jun,Liu, Xiangmei,Cui, Zhenduo,et al. Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light[J]. ADVANCED MATERIALS,2018.
APA	Li, Jun.,Liu, Xiangmei.,Cui, Zhenduo.,Yang, Xianjin.,Zhu, Shengli.,...&Wu, Shuilin.(2018).Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light.ADVANCED MATERIALS.
MLA	Li, Jun,et al."Rapid Biofilm Eradication on Bone Implants Using Red Phosphorus and Near-Infrared Light".ADVANCED MATERIALS (2018).